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Journal of Gastrointestinal Cancer

, Volume 41, Issue 4, pp 254–256 | Cite as

The Development of Gastric Cancer in a Patient with Polycythemia Vera, 3P Deletion, and JAK2 V617F Mutation

  • Ozlem Ayvaz
  • Irfan YavasogluEmail author
  • Gurhan Kadikoylu
  • Nezih Meydan
  • Sabri Barutca
  • Zahit Bolaman
Brief Communication
  • 125 Downloads

Abstract

3p deletion which is frequently associated with solitary tumors and hematological malignancies is a chromosomal abnormality. Recently, Janus kinase-2 (JAK2) V617F mutation has an important role in the diagnosis of myeloproliferative disorders, especially in polycythemia vera (PV). We reported the development of gastric cancer in a 75-year-old patient with PV, 3p 12-14 deletion and JAK2 V617F mutation. PV was diagnosed according to the classification of World Health Organization. JAK2 V617F mutation with polymerase chain reaction and 3p12-14 deletion with cytogenetic examination of the bone marrow were detected. We investigated solitary tumors in the patient using computed tomographies of thorax, neck, ear, nose, and throat. However, they were normal. After 2 years, gastric cancer appeared in the patient. In conclusion, cytogenetic examination may be important in both the development and the diagnosis of hematological malignancies and solitary tumors. So the patients should be followed closely.

Keywords

3p deletion JAKV617F polycythemia vera gastric cancer 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ozlem Ayvaz
    • 1
  • Irfan Yavasoglu
    • 1
    Email author
  • Gurhan Kadikoylu
    • 1
  • Nezih Meydan
    • 2
  • Sabri Barutca
    • 2
  • Zahit Bolaman
    • 1
  1. 1.Division of HematologyAdnan Menderes University Medical FacultyAydinTurkey
  2. 2.Division of OncologyAdnan Menderes University Medical FacultyAydinTurkey

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