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Stem Cell Therapy Improves the Outcome of Liver Resection in Cirrhotics

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Abstract

Introduction

Significant proportions of liver cirrhotic patients develop hepatocellular carcinoma and have to undergo hepatic resection. The compromised cirrhotic liver cannot withstand further removal of hepatic tissue, thus, leading to postoperative complication and death.

Methods

In this study, we enrolled 20 patients having liver cirrhosis with hepatocellular carcinoma and randomly assigned them into two groups to receive autologous stem cells or placebo.

Results

After 3 weeks, all participants underwent liver resection and were followed for 12 weeks postoperative. We observed that the group receiving preoperative stem cell therapy had shown a significant improvement in all parameters of liver function and had no postoperative complications compared to the group treated with placebo, which showed no improvement in liver parameters and had postoperative complications.

Discussion

In conclusion, autologous stem cell therapy can improve the surgical outcome in cirrhotic livers and should be considered as an adjuvant treatment in such patients undergoing hepatic resection.

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Authors and Affiliations

  1. General Surgery, Liver Research Unit, Stem Cell Research Division, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    Alaa Ismail

  2. Department of Surgery, Ain Shams University, Cairo, Egypt

    Ossama Fouad

  3. Department of Pathology, Cairo University, Cairo, Egypt

    Amr Abdelnasser

  4. Liver Research Unit, Ain Shams University, Cairo, Egypt

    Andaleeb Chowdhury

  5. Osteotech Inc., Eatontown, NJ, 07724, USA

    Abdulhafez Selim

  6. 1 El-Tadhya Sq. Triumph, Heliopolis, Cairo, Egypt

    Alaa Ismail

Authors
  1. Alaa Ismail
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  2. Ossama Fouad
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  3. Amr Abdelnasser
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  4. Andaleeb Chowdhury
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  5. Abdulhafez Selim
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Correspondence to Alaa Ismail.

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Ismail, A., Fouad, O., Abdelnasser, A. et al. Stem Cell Therapy Improves the Outcome of Liver Resection in Cirrhotics. J Gastrointest Canc 41, 17–23 (2010). https://doi.org/10.1007/s12029-009-9092-9

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  • DOI: https://doi.org/10.1007/s12029-009-9092-9

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