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Brain Swelling in Acute Liver Failure: From an Autopsy “Artifact” to a Treatable Complication

  • Neurocritical Care Through History
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References

  1. Adams RD, Foley JM. The neurological disorder associated with liver disease. Res Publ Assoc Res Nerv Ment Dis. 1953;32:198–237.

    CAS  PubMed  Google Scholar 

  2. Love S, Perry A, Ironside J, Budka H, editors. Greenfield’s neuropathology. 9th ed. Boca Raton: CRC Press; 2015.

    Google Scholar 

  3. Louis ED, Mayer SA, Noble JM, editors. Merritt’s neurology. 14th ed. Philadelphia: LWW; 2021.

    Google Scholar 

  4. Ropper AH, Samuels MA, Klein JP, Prasad S, editors. Adams and Victor’s principles of neurology. 11th ed. New York: McGraw Hill; 2019.

    Google Scholar 

  5. Ware AJ, D’Agostino AN, Combes B. Cerebral edema: a major complication of massive hepatic necrosis. Gastroenterology. 1971;61:877–84.

    Article  CAS  PubMed  Google Scholar 

  6. Plum F, Posner J. The diagnosis of stupor and coma. 1st ed. Philadelphia: F. A. Davis; 1966.

    Google Scholar 

  7. Posner JB, Saper CB, Schiff N, Plum F, editors. Plum and Posner’s diagnosis of stupor and coma. New York: Oxford University Press; 2007.

    Google Scholar 

  8. Rodgers JB, Mallory GK, Davidson DS. Massive liver cell necrosis; a retrospective study. Arch Intern Med. 1964;114:637–46.

    Article  CAS  PubMed  Google Scholar 

  9. Caravati CM, Wootton P. Acute massive hepatic necrosis with fatal liver failure. South Med J. 1962;55:1268–77.

    Article  CAS  PubMed  Google Scholar 

  10. Miyai K, Ruebner BH. Acute yellow atrophy, cirrhosis, and hepatoma. Arch Path. 1963;75:609–17.

    Google Scholar 

  11. Record CO, Chase RA, Hughes RD, Murray-Lyon IA, Williams R. Glycerol therapy for cerebral edema complicating fulminant hepatic failure. Br Med J. 1975;2:540.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Canalese J, Gimson AE, Davis C, Mellon PJ, Davis M, Williams R. Controlled trial of dexamethasone and mannitol for the cerebral edema of fulminant hepatic failure. Gut. 1982;23:625–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Bernal W, Hall C, Karvellas CJ, Auzinger G, Sizer E, Wendon J. Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure. Hepatology. 2007;46:1844–52.

    Article  CAS  PubMed  Google Scholar 

  14. Butterworth RF. Hepatic encephalopathy: a central neuroinflammatory disorder? Hepatology. 2011;53:1372–6.

    Article  PubMed  Google Scholar 

  15. Klatzo I. Presidental address. Neuropathological aspects of brain edema. J Neuropathol Exp Neurol. 1967;26:1–14.

    Article  CAS  PubMed  Google Scholar 

  16. Dixit V, Chang TM. Brain edema and the blood brain barrier in galactosamine-induced fulminant hepatic failure rats. An animal model for evaluation of liver support systems. ASAIO Trans. 1990;36:21–7.

    CAS  PubMed  Google Scholar 

  17. Olin P, Hausken J, Foss A, Karlsen TH, Melum E, Haugaa H. Continuous molecular adsorbent recirculating system treatment in 69 patients listed for liver transplantation. Scand J Gastroenterol. 2015;50:1127–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Wijdicks EF. Hepatic encephalopathy. N Engl J Med. 2016;375:1660–70.

    Article  CAS  PubMed  Google Scholar 

  19. Lee WM, Wijdicks EF. Fulminant hepatic failure: when the hepatologist meets the neurointensivist. Neurocrit Care. 2008;9:1–2.

    Article  PubMed  Google Scholar 

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  1. Division of Neurocritical Care and Hospital Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA

    Eelco F. M. Wijdicks

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  1. Eelco F. M. Wijdicks
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Wijdicks, E.F.M. Brain Swelling in Acute Liver Failure: From an Autopsy “Artifact” to a Treatable Complication. Neurocrit Care 40, 791–794 (2024). https://doi.org/10.1007/s12028-022-01445-y

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