Skip to main content
SpringerLink
Log in

An Uncommon Case of Hyperammonemic Encephalopathy

  • Practical Pearl
  • Published:
Neurocritical Care Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Drayna CJ, Titcomb CP, Varma RR, Soergel KH. Hyperammonemic encephalopathy caused by infection in a neurogenic bladder. N Engl J Med. 1981;304(13):766–8.

    Article  CAS  Google Scholar 

  2. Albersen M, Joniau S, Van Poppel H, Cuyle PJ, Knockaert DC, Meersseman W. Urea-splitting urinary tract infection contributing to hyperammonemic encephalopathy. Nat Clin Pract Urol. 2007;4(8):455–8.

    Article  Google Scholar 

  3. Murray T, Comeau LL. Hyperammonemic coma caused by Providencia rettgeri infection in a child with prune belly syndrome. Pediatr Crit Care Med. 2001;2(2):178–80.

    Article  CAS  Google Scholar 

  4. Auron A, Brophy PD. Hyperammonemia in review: pathophysiology, diagnosis, and treatment. Pediatr Nephrol. 2012;27(2):207–22.

    Article  Google Scholar 

  5. Felipo V. Hepatic encephalopathy: effects of liver failure on brain function. Nat Rev Neurosci. 2013;14(12):851–8.

    Article  CAS  Google Scholar 

  6. Summar ML, Barr F, Dawling S, et al. Unmasked adult-onset urea cycle disorders in the critical care setting. Crit Care Clin. 2005;21(4 Suppl):S1–8.

    Article  Google Scholar 

  7. Sakusic A, Sabov M, McCambridge AJ, et al. Features of adult hyperammonemia not due to liver failure in the ICU. Crit Care Med. 2018;46(9):e897–903.

    Article  CAS  Google Scholar 

  8. Lewis C, Deshpande A, Tesar GE, Dale R. Valproate-induced hyperammonemic encephalopathy: a brief review. Curr Med Res Opin. 2012;28(6):1039–42.

    Article  CAS  Google Scholar 

  9. Ullman MA, Haecker TA, Medani CR. Hyperammonemic encephalopathy and urinary obstruction. N Engl J Med. 1981;304:1546.

    CAS  PubMed  Google Scholar 

  10. Diamond DA, Blight A, Ransley PG. Hyperammonemic encephalopathy: a complication associated with the prune belly syndrome. J Urol. 1989;142(2 Pt 1):361–2.

    Article  CAS  Google Scholar 

  11. Grill MF, Maganti R. Cephalosporin-induced neurotoxicity: clinical manifestations, potential pathogenic mechanisms, and the role of electroencephalographic monitoring. Ann Pharmacother. 2008;42(12):1843–50.

    Article  CAS  Google Scholar 

  12. Payne LE, Gagnon DJ, Riker RR, et al. Cefepime-induced neurotoxicity: a systematic review. Crit Care. 2017;21(1):276.

    Article  Google Scholar 

  13. Hirsch LJ, LaRoche SM, Gaspard N, et al. American clinical Neurophysiology society’s standardized critical care EEG terminology: 2012 version. J Clin neurophysiol. 2013;30(1):1–2.

    Article  CAS  Google Scholar 

  14. Gaspard N. ACNS critical care EEG terminology: value, limitations, and perspectives. J Clin Neurophysiol. 2015;32(6):452–5.

    Article  Google Scholar 

  15. Sully KE, Husain AM. Generalized periodic discharges: a topical review. J Clin Neurophysiol. 2018;35(3):199–207.

    Article  Google Scholar 

  16. Sutter R, Kaplan PW. Clinical and electroencephalographic correlates of acute encephalopathy. J Clin Neurophysiol. 2013;30(5):443–53.

    Article  Google Scholar 

  17. Faigle R, Sutter R, Kaplan PW. Electroencephalography of encephalopathy in patients with endocrine and metabolic disorders. J Clin Neurophysiol. 2013;30(5):505–16.

    Article  Google Scholar 

  18. Boulanger JM, Deacon C, Lécuyer D, Gosselin S, Reiher J. Triphasic waves versus nonconvulsive status epilepticus: EEG distinction. Can J Neurol Sci. 2006;33(2):175–80.

    Article  Google Scholar 

  19. Sutter R, Stevens RD, Kaplan PW. Significance of triphasic waves in patients with acute encephalopathy: a nine-year cohort study. Clin Neurophysiol. 2013;124(10):1952–8.

    Article  Google Scholar 

Download references

Acknowledgements

The actual affiliation of Dr. Frazzini is at AP-HP, Epilepsy Unit, Pitié-Salpêtrière Hospital and at ICM (Brain and Spine Institute; INSERM UMRS1127, CNRS UMR7225, Sorbonne Université), Pitié-Salpêtrière Hospital, Paris, France. However, the patient’s admission, clinical management, and paper writing were realized during his previous stay at the Department of Neuroscience, Imaging and Clinical Sciences, “G.d’Annunzio” University, Chieti-Pescara, Italy.

Funding

This study was not sponsored.

Author information

Authors and Affiliations

  1. AP-HP, Epilepsy Unit, Pitié-Salpêtrière Hospital and Brain and Spine Institute (INSERM UMRS1127, CNRS UMR7225, Sorbonne Université), Pitié-Salpêtrière Hospital, Paris, France

    Valerio Frazzini

  2. Department of Neuroscience, Imaging and Clinical Sciences, “G.d’Annunzio” University, Chieti-Pescara, and Neurology Clinics, SS Annunziata Hospital, Chieti-Pescara, Italy

    Valerio Frazzini, Margherita Capasso & Marco Onofrj

Authors
  1. Valerio Frazzini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Margherita Capasso
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marco Onofrj
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

VF study concept, interpretation and revision of the clinical data, manuscript writing. MC analysis and interpretation of the clinical data. Critical revision of the manuscript. MO paper supervision. Critical revision of the manuscript.

Corresponding author

Correspondence to Valerio Frazzini.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Frazzini, V., Capasso, M. & Onofrj, M. An Uncommon Case of Hyperammonemic Encephalopathy. Neurocrit Care 31, 439–442 (2019). https://doi.org/10.1007/s12028-019-00715-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12028-019-00715-6

Keywords

Search

Navigation