Neurocritical Care

, Volume 30, Issue 1, pp 62–71 | Cite as

Prediction of Delayed Cerebral Ischemia with Cerebral Angiography: A Meta-Analysis

  • Gyanendra KumarEmail author
  • Oana M. Dumitrascu
  • Chia-Chun Chiang
  • Cumara B. O’Carroll
  • Andrei V. Alexandrov
Original Article



Cerebral catheter angiography is the gold standard for diagnosing cerebral artery vasospasm (vasospasm) in aneurysmal subarachnoid hemorrhage (SAH). We have previously published a meta-analysis of prediction of delayed cerebral ischemia (DCI) from transcranial Doppler (TCD) evidence of vasospasm. Analogous data relating to prediction of DCI have not been previously collated for cerebral angiography nor reconciled against TCD.


We searched PUBMED, the Cochrane database, and for studies that used cerebral angiography for diagnosis of vasospasm and evaluated DCI in patients with SAH. We performed a random-effects meta-analysis of prediction of DCI with cerebral angiography, reconciling its accuracy against that of TCD. We also report quality of evidence for the value of cerebral angiography and TCD in SAH based on pooled data from our meta-analyses.


A total of 15 studies (n = 5463) were included in the meta-analysis. Sensitivity (SN), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV) of cerebral angiography for prediction of DCI are 57, 68, 32, and 90%. These metrics for TCD, based on our previous meta-analysis, are 90, 71, 57, and 92%. We report that test accuracy estimates are “moderate” for TCD and “low” for angiography based on pooled data from our meta-analyses.


TCD evidence of vasospasm is a better predictor of DCI than angiographic vasospasm. Future comparative effectiveness studies can better define the value of these diagnostic tools in patients with SAH.


Meta-analysis Brain ischemia Cerebral vasospasm Cerebral angiography Transcranial Doppler sonography 


Author Contributions

GK contributed to study conception, design, acquisition of data, analysis, statistical analysis, writing of manuscript, critical revision, study supervision, and final approval. OMD helped in acquisition of data, analysis, writing of manuscript, critical revision, and final approval. CCC contributed to acquisition of data, analysis, writing of manuscript, critical revision, and final approval. COC involved in analysis, supervision, writing and critical revision, and final approval. AVA helped in analysis, supervision, writing and critical revision, and final approval.

Source of support


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

12028_2018_572_MOESM1_ESM.pdf (297 kb)
Supplementary material 1 (PDF 297 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society 2018

Authors and Affiliations

  1. 1.Division of Cerebrovascular Diseases, Department of NeurologyMayo ClinicPhoenixUSA
  2. 2.Department of NeurologyCedars-Sinai Medical CenterLos AngelesUSA
  3. 3.Department of NeurologyUniversity of Tennessee Health Science CenterMemphisUSA

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