Abstract
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. In large part critical care for TBI is focused on the identification and management of secondary brain injury. This requires effective neuromonitoring that traditionally has centered on intracranial pressure (ICP). The purpose of this paper is to review the fundamental literature relative to the clinical application of ICP monitoring in TBI critical care and to provide recommendations on how the technique maybe applied to help patient management and enhance outcome. A PubMed search between 1980 and September 2013 identified 2,253 articles; 244 of which were reviewed in detail to prepare this report and the evidentiary tables. Several important concepts emerge from this review. ICP monitoring is safe and is best performed using a parenchymal monitor or ventricular catheter. While the indications for ICP monitoring are well established, there remains great variability in its use. Increased ICP, particularly the pattern of the increase and ICP refractory to treatment is associated with increased mortality. Class I evidence is lacking on how monitoring and management of ICP influences outcome. However, a large body of observational data suggests that ICP management has the potential to influence outcome, particularly when care is targeted and individualized and supplemented with data from other monitors including the clinical examination and imaging.
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Conflict of interest
Randall Chesnut receives NIH funding. Peter Le Roux receives research funding from Integra Lifesciences, Neurologica, the Dana Foundation, and the NIH; is a consultant for Integra Lifesciences, Codman, Synthes, Neurologica; and is a member of the scientific advisory board of Cerebrotech, Brainsgate, Orsan and Edge Therapeutics. Paul Vespa receives Grant Funding from NIH, DOD; is a consultant for Edge Therapeutics; and has Stock Options with Intouch Health. Walter Videtta receives NIH funding.
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The Participants in the International Multidisciplinary Consensus Conference on Multimodality Monitoring are listed in “Appendix” section.
Appendix: Participants in the International Multi-disciplinary Consensus Conference on Multimodality Monitoring
Appendix: Participants in the International Multi-disciplinary Consensus Conference on Multimodality Monitoring
Peter Le Roux, MD, FACS,
Brain and Spine Center,
Suite 370, Medical Science Building,
Lankenau Medical Center,
100 East Lancaster Avenue, Wynnewood, PA 19096, USA.
Tel: +1 610 642 3005;
Fax: 610 642 3057
lerouxp@mlhs.org
David K Menon MD PhD FRCP FRCA FFICM FMedSci
Head, Division of Anaesthesia, University of Cambridge
Consultant, Neurosciences Critical Care Unit
Box 93, Addenbrooke’s Hospital,
Cambridge CB2 2QQ, UK
dkm13@wbic.cam.ac.uk
Paul Vespa, MD, FCCM, FAAN, FNCS
Professor of Neurology and Neurosurgery
Director of Neurocritical Care
David Geffen School of Medicine at UCLA
Los Angeles, CA 90095 USA
PVespa@mednet.ucla.edu
Giuseppe Citerio, MD
Director NeuroIntensive Care Unit,
Department of Anesthesia and Critical Care
Ospedale San Gerardo, Monza.
Via Pergolesi 33, Monza 20900, Italy
g.citerio@hsgerardo.org
Mary Kay Bader RN, MSN, CCNS, FAHA, FNCS
Neuro/Critical Care CNS
Mission Hospital
Mission Viejo CA 92691, USA
Marykay.Bader@stjoe.org
Gretchen M. Brophy, PharmD, BCPS, FCCP, FCCM
Professor of Pharmacotherapy & Outcomes Science and Neurosurgery
Virginia Commonwealth University
Medical College of Virginia Campus
410 N. 12th Street
Richmond, Virginia 23298-0533 USA
gbrophy@vcu.edu
Michael N. Diringer, MD
Professor of Neurology, Neurosurgery & Anesthesiology
Chief, Neurocritical Care Section
Washington University
Dept. of Neurology, Campus Box 8111
660 S Euclid Ave
St Louis, MO 63110 USA
diringerm@neuro.wustl.edu
Nino Stocchetti, MD
Professor of Anesthesia and Intensive Care
Department of physiopathology and transplant,
Milan University
Director Neuro ICU
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
Via F Sforza, 35 20122 Milan Italy
e-mail stocchet@policlinico.mi.it
Walter Videtta, MD
ICU Neurocritical Care
Hospital Nacional ‘Prof. a. Posadas’
El Palomar - Pcia. de Buenos Aires
Argentina
wvidetta@ar.inter.net
Rocco Armonda, MD
Department of Neurosurgery
MedStar Georgetown University Hospital
Medstar Health, 3800 Reservoir Road NW
Washington DC 20007
USA
Rocco.Armonda@gmail.com
Neeraj Badjatia, MD
Department of Neurology
University of Maryland Medical Center,
22 S Greene St
Baltimore, MD, 21201
USA
nbadjatia@umm.edu
Julian Boesel, MD
Department of Neurology
Ruprect-Karls University
Hospital Heidelberg, Im Neuenheimer Feld 400,
D-69120 Heidelberg,
Germany
Julian.Boesel@med.uni-heidelberg.de
Randal Chesnut, MD, FCCM, FACS
Harborview Medical Center,
University of Washington Mailstop 359766
325 Ninth Ave,
Seattle WA 98104-2499
USA
chesnutr@u.washington.edu
Sherry Chou, MD, MMSc
Department of Neurology,
Brigham and Women’s Hospital
75 Francis Street,
Boston MA 02115
USA
schou1@partners.org
Jan Claassen, MD, PhD, FNCS
Assistant Professor of Neurology and Neurosurgery
Head of Neurocritical Care and Medical Director of the Neurological Intensive Care Unit
Columbia University College of Physicians & Surgeons
177 Fort Washington Avenue, Milstein 8 Center room 300,
New York, NY 10032
USA
jc1439@cumc.columbia.edu
Marek Czosnyka, PhD
Department of Neurosurgery
University of Cambridge,
Addenbrooke’s Hospital, Box 167
Cambridge, CB20QQ
United Kingdom
mc141@medschl.cam.ac.uk
Michael De Georgia, MD
Professor of Neurology
Director, Neurocritical Care Center
Co-Director, Cerebrovascular Center
University Hospital Case Medical Center
Case Western Reserve University School of Medicine
11100 Euclid Avenue
Cleveland, Ohio 44106
michael.degeorgia@uhhospitals.org
Anthony Figaji, MD, PhD
Head of Pediatric Neurosurgery
University of Cape Town
617 Institute for Child Health
Red Cross Children’s Hospital
Rondebosch, 7700 Cape Town,
South Africa
anthony.figaji@uct.ac.za
Jennifer Fugate, DO
Department of Neurology,
Mayo Clinic,
200 First Street SW
Rochester, MN 55905
Fugate.Jennifer@mayo.edu
Raimund Helbok, MD
Department of Neurology, Neurocritical Care Unit
Innsbruck Medical University,
Anichstr.35, 6020
Innsbruck,
Austria
raimund.helbok@uki.at
David Horowitz, MD
Associate Chief Medical Officer
University of Pennsylvania Health System,
3701 Market Street
Philadelphia, PA, 19104
USA
david.horowitz@uphs.upenn.edu
Peter Hutchinson, MD
Professor of Neurosurgery
NIHR Research Professor
Department of Clinical Neurosciences
University of Cambridge
Box 167 Addenbrooke’s Hospital
Cambridge CB2 2QQ
United Kingdom
pjah2@cam.ac.uk
Monisha Kumar, MD
Department of Neurology
Perelman School of Medicine, University of Pennsylvania,
3 West Gates
3400 Spruce Street
Philadelphia, PA, 19104
USA
monisha.kumar@uphs.upenn.edu
Molly McNett, RN, PhD
Director, Nursing Research
The MetroHealth System
2500 MetroHealth Drive,
Cleveland, OH 44109
USA
mmcnett@metrohealth.org
Chad Miller, MD
Division of Cerebrovascular Diseases and Neurocritical Care
The Ohio State University
395 W. 12th Ave, 7th Floor
Columbus, OH 43210
ChadM.Miller@osumc.edu
Andrew Naidech, MD, MSPH
Department of Neurology
Northwestern University Feinberg SOM 710
N Lake Shore Drive, 11th floor
Chicago, IL 60611
ANaidech@nmff.org
Mauro Oddo, MD
Department of Intensive Care Medicine
CHUV University Hospital, BH 08-623
Faculty of Biology and Medicine University of Lausanne
1011 Lausanne, Switzerland
Mauro.Oddo@chuv.ch
DaiWai Olson, RN, PhD
Associate Professor of Neurology, Neurotherapeutics and Neurosurgery
University of Texas Southwestern
5323 Harry Hines Blvd.
Dallas, TX 75390-8897
USA
daiwai.olson@utsouthwestern.edu
Kristine O’Phelan M.D.
Director of Neurocritical Care
Associate Professor, Department of Neurology
University of Miami, Miller School of Medicine
JMH, 1611 NW 12th Ave, Suite 405
Miami, FL, 33136
USA
kophelan@med.miami.edu
Javier Provencio, MD
Associate Professor of Medicine
Cerebrovascular Center and Neuroinflammation Research Center
Lerner College of Medicine
Cleveland Clinic,
9500 Euclid Ave, NC30
Cleveland, OH 44195
USA
provenj@ccf.org
Corina Puppo, MD
Assistant Professor, Intensive Care Unit,
Hospital de Clinicas, Universidad de la República,
Montevideo
Uruguay
coripuppo@gmail.com
Richard Riker, MD
Critical Care Medicine
Maine Medical Center,
22 Bramhall Street
Portland, Maine 04102-3175
USA
RRiker@cmamaine.com
Claudia Robertson, MD
Department of Neurosurgery
Medical Director of Center for Neurosurgical Intensive Care,
Ben Taub Hospital
Baylor College of Medicine,
1504 Taub Loop, Houston, TX 77030
USA
claudiar@bcm.tmc.edu
J. Michael Schmidt, PhD, MSc
Director of Neuro-ICU Monitoring and Informatics
Columbia University College of Physicians and Surgeons
Milstein Hospital 8 Garden South, Suite 331
177 Fort Washington Avenue,
New York, NY 10032
USA
mjs2134@columbia.edu
Fabio Taccone, MD
Department of Intensive Care, Laboratoire de Recherche Experimentale
Erasme Hospital,
Route de Lennik, 808
1070 Brussels
Belgium
ftaccone@ulb.ac.be
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Chesnut, R., Videtta, W., Vespa, P. et al. Intracranial Pressure Monitoring: Fundamental Considerations and Rationale for Monitoring. Neurocrit Care 21 (Suppl 2), 64–84 (2014). https://doi.org/10.1007/s12028-014-0048-y
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DOI: https://doi.org/10.1007/s12028-014-0048-y