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QTc Interval and Neurological Outcomes in Aneurysmal Subarachnoid Hemorrhage

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Abstract

Background

Prolonged heart rate-corrected QT (QTc) interval is frequently observed in subarachnoid hemorrhage (SAH). This study was conducted to determine the relationship between QTc interval and neurological outcome during the acute posthemorrhagic period after aneurysmal SAH.

Methods

We studied 71 patients undergoing surgery who were admitted within 24 h after the onset of aneurysmal SAH. Standard 12-lead electrocardiography was performed on admission (T1) and at 1 and 7 days after operation (T2 and T3). QT intervals were corrected by heart rate according to the Fridericia formula. The Glasgow Coma Scale (GCS) score was calculated over the period T1–T3. Neurological outcome was assessed using the Glasgow Outcome Scale at hospital discharge.

Results

Among the 71 patients, 31 had an unfavorable neurological outcome. Although QTc interval prolongation improved in patients with a good outcome, QTc interval prolongation continued in patients with an unfavorable outcome. The areas under the receiver–operator characteristic curves showed that the QTc and GCS score at T3, and the Hunt and Hess grade were significant predictors of an unfavorable neurological outcome. The threshold value, sensitivity, and specificity for the QTc at T3 were 448 ms, 73% [95% confidence interval (CI), 68–78], and 93% (95% CI, 90–96), respectively.

Conclusion

This study confirms that QTc interval prolongation continues in the SAH patients with an unfavorable outcome but that QTc interval prolongation improves in patients with a good outcome, suggesting that a QTc interval of more than 448 ms at 7 days after operation is a predictor of neurological outcome after SAH.

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Acknowledgements

This study was supported, in part, by research funds to promote the hospital functions of Japan Labor Health and Welfare Organization.

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Authors and Affiliations

  1. Department of Anesthesia, Nagasaki Rosai Hospital, 2-12-5 Setogoe, Sasebo, 857-0134, Japan

    Taiga Ichinomiya, Yoshiaki Terao, Kosuke Miura, Ushio Higashijima, Tomomi Tanise & Makoto Fukusaki

  2. Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Koji Sumikawa

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  1. Taiga Ichinomiya
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  2. Yoshiaki Terao
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Correspondence to Yoshiaki Terao.

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Ichinomiya, T., Terao, Y., Miura, K. et al. QTc Interval and Neurological Outcomes in Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care 13, 347–354 (2010). https://doi.org/10.1007/s12028-010-9411-9

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