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Listeria monocytogenes Meningitis Associated with Rhabdomyolysis and Acute Renal Failure



Numerous systemic infections are capable of inducing myositis and rhabdomyolysis. Clinical course of the disease is in the great majority of patients benign and without development of renal dysfunction. However, serious consequences are possible if acute renal failure (ARF) occurs, especially in critically ill patients.


Patient with Listeria monocytogenes meningitis associated with rhabdomyolysis and acute non-oliguric ARF is presented.


Sixty-nine-year-old white male was admitted to our intensive care unit because of listerial meningitis. The course of the disease was complicated with rhabdomyolysis and non-oliguric ARF. After antimicrobial treatment with parenteral trimethoprim-sulfamethoxazole and 4 days of continuous veno-venous hemodiafiltration (CVVHDF) the patient recovered.


We report a case of listerial meningitis complicated with non-oliguric ARF. Rhabdomyolysis should be considered in all patients with infection and increased CK, especially if consciousness is impaired is altered. Furthermore, despite the normal diuresis ARF could be present and result in adverse consequences. We infer that timely diagnosis and treatment should improve the outcome of infection-induced rhabdomyolysis and could prevent a proportion of associated ARF.

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  1. 1.

    Gabow PA, Kaehny WD, Kelleher SP. The spectrum of rhabdomyolysis. Medicine. 1982;61:141–52.

    PubMed  Article  CAS  Google Scholar 

  2. 2.

    Bartalesi F, Borchi B, Grilli E, Corti G, Bartoloni A. Late-onset rhabdomyolysis in pneumococcal meningitis: a case report. Intern Emerg Med. 2007;2(3):233–5.

    Google Scholar 

  3. 3.

    Blanco JR, Zabalza M, Salcedo J, Echeverria L, García A, Vallejo M. Rhabdomyolysis of infectious and noninfectious causes. South Med J. 2002;95(5):542–4.

    PubMed  Google Scholar 

  4. 4.

    Thomas F, Ravaud Y. Rhabdomyolysis and acute renal failure associated with Listeria meningitis. J Infect Dis. 1988;158(2):492–3.

    PubMed  CAS  Google Scholar 

  5. 5.

    Clark P, Lough M, Whiting B. Rhabdomyolysis and Listeria monocytogenes. Scott Med J. 1989;34(4):503.

    PubMed  CAS  Google Scholar 

  6. 6.

    Rudi K, Nogva HK, Naterstad K, Dromtorp SM, Bredholt S, Holck A. Subtyping Listeria monocytogenes through the combined analyses of genotype and expression of the hlya virulence determinant. J Appl Microbiol. 2003;94:720–32.

  7. 7.

    Schrier RW, Wang W. Acute renal failure and sepsis. N Engl J Med. 2004;351(2):159–69.

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Faubel S, Lewis EC, Reznikov L, et al. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther. 2007;322(1):8–15.

    PubMed  Article  CAS  Google Scholar 

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We thank Mrs. Arijana Pavelić for her help in the preparation of this manuscript.

Financial disclosure

Supported by the grant from the Croatian Ministry of Science, Education and Sports: No. 108-1080002-0102.

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Correspondence to Marko Kutleša.

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Kutleša, M., Lepur, D., Bukovski, S. et al. Listeria monocytogenes Meningitis Associated with Rhabdomyolysis and Acute Renal Failure. Neurocrit Care 10, 70–72 (2009).

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  • Listeria monocytogenes
  • Rhabdomyolysis
  • Meningitis
  • Creatine kinase
  • Acute renal failure