This study was supported by grants from the National Natural Science Foundation of Guangdong (2015A030313332 and 2017A030310456), the Medical Scientific Research Foundation of Guangdong Province (A2018271 and A2019221), the Science Research and Innovation Foundation of Jinan University (21617493 and 21617481), and the Science Research and Cultivate Foundation from the First Clinical Medical College of Jinan University (2016320, 2017105, and 2018108).