Immunologic Research

, Volume 67, Issue 1, pp 134–141 | Cite as

The coexistence of pemphigus and psoriasis: a systematic review and meta-analysis

  • Khalaf KridinEmail author
  • Mouhammad Kridin
  • Guy Shalom
  • Arnon D. Cohen
Original Article


There is little consensus regarding the association between pemphigus and psoriasis. The aim of the current study is to synthesize existing data on the prevalence of psoriasis in patients with pemphigus and on the association between the two conditions. We performed a systematic review and meta-analysis of observational studies in Medline, Embase, and Web of Science (1900–2018). Reference lists of included studies were also searched for eligible studies. Quality of evidence was assessed using Newcastle-Ottawa scale (NOS). A meta-analysis was performed using random-effects models to estimate pooled prevalence rates and odds ratios (ORs) with 95% confidence intervals (CI). Subgroup and sensitivity analyses were also conducted. Twelve eligible studies comprising 12,238 patients with pemphigus were included in the quantitative synthesis. The overall random-effects pooled prevalence of psoriasis among patients with pemphigus was 2.4% (95% CI, 1.0–4.4) across all studies. The overall pooled multivariate OR for psoriasis in patients with pemphigus was significantly increased and estimated at 3.5 (95% CI, 1.6–7.6). In conclusion, a significant association was found between pemphigus and psoriasis. Physicians managing patients with pemphigus may be aware of this comorbidity. Further studies are warranted to establish the precise mechanisms underlying this relationship.


Pemphigus Psoriasis Association Meta-analysis Systematic review 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interests.

Supplementary material

12026_2018_9031_MOESM1_ESM.pptx (50 kb)
Supplementary figure 1 Funnel plot for all the included studies reporting the prevalence of psoriasis in patients with pemphigus. (PPTX 49 kb)
12026_2018_9031_MOESM2_ESM.pptx (50 kb)
Supplementary figure 2 Funnel plot for all the included studies reporting the OR for psoriasis in patients with pemphigus. (PPTX 49 kb)
12026_2018_9031_MOESM3_ESM.docx (16 kb)
ESM 3 (DOCX 15 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of DermatologyRambam Health Care CampusHaifaIsrael
  2. 2.Sackler School of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Clalit Health Services, Yavne, Faculty of Health SciencesBen-Gurion University of the NegevBeer-ShevaIsrael
  4. 4.Department of Quality Measurements and ResearchChief Physician’s Office, Clalit Health ServicesTel AvivIsrael
  5. 5.Siaal Research Center for Family Medicine and Primary Care, Faculty of Health SciencesBen-Gurion University of the NegevBeer-ShevaIsrael

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