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Immunologic Research

, Volume 66, Issue 2, pp 219–223 | Cite as

T cell receptor-β J usage, in combination with particular HLA class II alleles, correlates with better cancer survival rates

  • Blake M. Callahan
  • Wei Lue Tong
  • George Blanck
Original Article

Abstract

T cell receptor (TCR) β V and J usage correlates with either the HLA class I or HLA class II major histocompatibility subtypes, and in both infectious diseases and autoimmune settings, the use of particular TCR-β V and J’s, in persons with specific HLA alleles, represents either better outcomes or certain clinical features. However, the relationship of TCR V and J usage, HLA alleles, and clinical parameters in the cancer setting has been less well studied. Here, we have evaluated the relationship of what is likely dominant TCR-β V and J usage among tissue-resident lymphocytes for lung, head and neck, kidney, stomach, ovarian, and endometrial cancers, with patient HLA class II alleles. The most striking indication is that TCR-β J subgroup usage, in combination with particular patient HLA class II alleles, correlated with either better or worse outcomes for lung cancer. One combination, TCR-β J2 segment usage and the HLA-DRB1*1501 allele, correlated with a better survival rate for both lung and head and neck cancers. These results fill a gap in knowledge regarding the relevance of HLA typing to cancer and indicate that HLA typing, along with an indication of dominant TCR-β J usage among tissue-resident lymphocytes, can be useful for prognosis.

Keywords

T cell receptor-β HLA class I and class II proteins Antigen presentation Cancer immune response The Cancer Genome Atlas 

Abbreviations

HNSC

Head and neck squamous carcinoma

KIRC

Kidney and renal carcinoma

LUAD

Lung adenocarcinoma

OV

Ovarian cancer

TCGA

The Cancer Genome Atlast

UCEC

Uterine corpus and endometrial carcinoma

Notes

Acknowledgements

Authors would like to acknowledge the support of USF Research Computing and the taxpayers of the State of Florida. BMC was a recipient of a Bonati scholarship.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

12026_2018_8990_MOESM1_ESM.pdf (6 mb)
ESM 1 (PDF 6142 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Molecular Medicine, Morsani College of MedicineUniversity of South FloridaTampaUSA
  2. 2.Immunology ProgramH. Lee Moffitt Cancer and Research InstituteTampaUSA

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