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Chronic hepatitis C viral infection among SLE patients: the significance of coexistence


The association between viral infection and autoimmune diseases is an established phenomenon in medicine. Hepatitis C viral infection is known to have such an association; however, its association with systemic lupus erythematosus has not been studied in a real life study driven from a large national database. The objective of this study was to investigate the association between SLE and chronic hepatitis C viral infection. Patients with SLE were compared with age- and sex-matched controls regarding the proportion chronic HCV infection. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services in Israel. There was a significant higher proportion of hepatitis C viral infection in SLE patients as compared to controls (1.06 and 0.39%, respectively; p < 0.001). A significant association was also observed among patients of higher socioeconomic status. In a multivariate logistic regression analysis, SLE was significantly associated with hepatitis C viral infection (OR = 2.07, 95% CI = 1.46–2.90). To conclude, Patients with SLE have a greater proportion of chronic HCV infection than matched controls.

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Correspondence to Howard Amital.

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The study was approved by the ethical committee of CHS, located at the Soroka Medical Center, Beer Sheva, Israel.

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Mahroum, N., Hejly, A., Tiosano, S. et al. Chronic hepatitis C viral infection among SLE patients: the significance of coexistence. Immunol Res 65, 477–481 (2017).

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  • SLE
  • Hepatitis C
  • Autoimmune disease
  • Infections