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Postural tachycardia syndrome (POTS) with anti-NMDA receptor antibodies after human papillomavirus vaccination


We describe a young woman who developed POTS with positive serum anti-NMDA receptor antibodies and no evidence of encephalitis after vaccination with HPV vaccine, Cervarix. Her symptoms improved significantly with immunomodulatory therapy and re-occurred after immunomodulatory therapy was stopped, suggesting an autoimmune etiology of POTS after vaccination.

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Correspondence to Svetlana Blitshteyn.

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Blitshteyn, S., Brook, J. Postural tachycardia syndrome (POTS) with anti-NMDA receptor antibodies after human papillomavirus vaccination. Immunol Res 65, 282–284 (2017).

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  • Human papillomavirus vaccination
  • Postural tachycardia syndrome
  • Anti-NMDA receptor antibodies
  • Orthostatic intolerance
  • Plasmapheresis