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Integrative neuroscience approach to neuropsychiatric lupus

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Abstract

We present a succinct review of our approach to study the interactions between the DNA-reactive antibodies that cross-react with the GluN2A and GluN2B subunits of the N-methyl-d-aspartate receptor, denoted DNRABs, and their brain targets in subjects with neuropsychiatric systemic lupus erythematosus (NPSLE). We have analyzed the DNRAB-based brain symptomatology in mouse models of NPSLE by using an integrative neuroscience approach, which includes behavioral assessment coupled with electrophysiological studies of neural networks and synaptic connections in target brain regions, such as the CA1 region of the hippocampus. Our results suggest a framework for understanding the interactions between immune factors and neural networks.

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Acknowledgments

We thank Eric H. Chang, Thomas W. Faust, Sergio Robbiati, Stephen A. Frattini, Toby Klein, and all the members of the LOINN (Laboratory of Immune and Neural Networks) for their help in these studies. This research was funded by NIH Grant P01-AI073693 (to B.D., P.H., M.M., B.V.) and NIH Grant P01-AI102852 (to B.D., P.H., K.T., B.V.).

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    1. Laboratory of Immune and Neural Networks, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA

      Patricio T. Huerta, Elizabeth L. Gibson, Carson Rey & Tomás S. Huerta

    2. Department of Molecular Medicine, Hofstra North Shore LIJ Medical School, Hempstead, NY, USA

      Patricio T. Huerta

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    1. Patricio T. Huerta
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    Correspondence to Patricio T. Huerta.

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    Patricio T. Huerta, Elizabeth L. Gibson, Carson Rey and Tomás S. Huerta have contributed equally to this work.

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    Huerta, P.T., Gibson, E.L., Rey, C. et al. Integrative neuroscience approach to neuropsychiatric lupus. Immunol Res 63, 11–17 (2015). https://doi.org/10.1007/s12026-015-8713-6

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