Immunologic Research

, Volume 60, Issue 1, pp 145–152

An analysis and decision tool to measure cost benefit of newborn screening for severe combined immunodeficiency (SCID) and related T-cell lymphopenia


DOI: 10.1007/s12026-014-8485-4

Cite this article as:
Modell, V., Knaus, M. & Modell, F. Immunol Res (2014) 60: 145. doi:10.1007/s12026-014-8485-4


Severe combined immunodeficiency (SCID) is a group of syndromes resulting from genetic defects causing absence in T-cell and B-cell function, leading to serious and life-threatening infections. SCID is often fatal in the first 2 years of life if not identified and properly treated. While additional laboratory methods are being developed, the current T-cell receptor excision circle assay has proven to have outstanding specificity and sensitivity to accurately identify infants with SCID and other T-cell lymphopenia. The Jeffrey Modell Foundation (JMF) has a long history of advocacy and continues to promote newborn screening for SCID to be implemented in the United States and worldwide. Based on reports provided by California, New York, Texas, and Wisconsin on the results of their population based newborn screening programs, the overall incidence of SCID averaged 1:33,000 and T-cell lymphopenia averaged 1:6,600. JMF has developed a working algorithm or “decision tree”, validated by peer-reviewed scientific literature, to be used by Public Health Departments and Health Ministries in states, countries, and regions throughout the world. This decision tool allows for local or regional data to be applied to measure the threshold and economic impact of implementing newborn screening for SCID and T-cell lymphopenia.


Newborn screening Severe combined immunodeficiency (SCID) T-cell lymphopenia TREC assay Bone marrow transplantation 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Jeffrey Modell FoundationNew YorkUSA

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