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Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes

  • Current Immunology Research at Jefferson
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Abstract

Cytotoxic T lymphocytes (CTL) play a critical role in immunity against viruses and cancer. The antigen receptor or T-cell receptor (TCR) on CTL determines the specificity toward target cells. The CD8 co-receptor functions in concert with the TCR to enhance TCR-mediated signaling, accounting for the remarkable sensitivity and swift signaling kinetics of the CTL response. The latter ensures efficient delivery and release of lytic granules, resulting in sensitive and rapid destruction of target cells.

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Acknowledgments

This work was supported by NIH grants to Yuri Sykulev (AI52812; CA131973). We are grateful to Larry Stern, Martin Poenie, Pierre Henkart and Philip Norris for critical reading of the manuscript and useful comments. This review is not meant to be comprehensive, but rather pursues a particular focus that reflects the views of the authors on the issues discussed.

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  1. Department of Microbiology and Immunology, Kimmel Cancer Center and Jefferson Vaccine Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA

    Nadia Anikeeva & Yuri Sykulev

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  1. Nadia Anikeeva
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  2. Yuri Sykulev
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Correspondence to Nadia Anikeeva or Yuri Sykulev.

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Anikeeva, N., Sykulev, Y. Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes. Immunol Res 51, 183–194 (2011). https://doi.org/10.1007/s12026-011-8252-8

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