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Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University

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Abstracts

Kidney ischemia/reperfusion injury (IRI) is a common and serious problem in hospitalized patients. Immune cell trafficking and leukocyte-endothelial adhesion potentiate kidney IRI. An important immunomodulatory role of T lymphocytes has been elucidated in IRI. Regulatory T cells are a lymphocyte subset that has recently been demonstrated to perform a protective role both in early injury from IRI as well as in later repair. The immune system also participates in distant organ effects during kidney IRI. Studies focusing on immune aspects of kidney IRI have enabled the discovery of promising novel therapeutic and diagnostic approaches.

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Acknowledgments

This work was supported by the NIDDK, NHLBI, NKF, and AHA. We are grateful to the many trainees and staff who have contributed to the work summarized in this article.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Ross 965, 720 Rutland Ave., Baltimore, MD, 21205, USA

    Gang Jee Ko, Asif Zakaria, Karl L. Womer & Hamid Rabb

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  1. Gang Jee Ko
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  2. Asif Zakaria
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Correspondence to Hamid Rabb.

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Ko, G.J., Zakaria, A., Womer, K.L. et al. Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University. Immunol Res 47, 78–85 (2010). https://doi.org/10.1007/s12026-009-8140-7

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