Immunologic Research

, Volume 47, Issue 1, pp 25–44

Mechanisms involved in antibody- and complement-mediated allograft rejection


DOI: 10.1007/s12026-009-8136-3

Cite this article as:
Wasowska, B.A. Immunol Res (2010) 47: 25. doi:10.1007/s12026-009-8136-3


Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to study pathogenesis of antibody- and complement-mediated endothelial cell injury leading to graft rejection. In this review, we discuss mechanisms of antibody-mediated graft rejection resulting from activation of complement by C1q- and MBL (mannose-binding lectin)-dependent pathways and interactions with a variety of effector cells, including macrophages and monocytes through Fcγ receptors and complement receptors.


Alloantibody Complement Ig knockout mice Cardiac rejection vWf C4d MBL Fcγ and complement receptors Endothelial cells Macrophages 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PathologyThe Johns Hopkins University School of MedicineBaltimoreUSA

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