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Enhancement of anti-tumor immunity by photodynamic therapy

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Abstract

Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumors, resulting in cure of early disease and palliation of advanced disease. PDT was originally considered to be a local treatment; however, both pre-clinical and clinical studies have shown that local PDT treatment of tumors can enhance systemic anti-tumor immunity. The current state of investigations into the ability of PDT to enhance anti-tumor immunity, the mechanisms behind this enhancement and the future of PDT as an immunotherapy are addressed in this review.

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Acknowledgments

This work was supported by NIH Grants CA55791 and CA98156 and in part by the Roswell Park Cancer Center Support Grant CA16056.

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Gollnick, S.O., Brackett, C.M. Enhancement of anti-tumor immunity by photodynamic therapy. Immunol Res 46, 216–226 (2010). https://doi.org/10.1007/s12026-009-8119-4

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