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Parameters influencing antigen-specific immunotherapy for Type 1 diabetes

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Abstract

Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which the insulin producing β cells are destroyed. Antigen-based immunotherapy provides an approach to selectively tolerize pathogenic β cell-specific T cells, while leaving the remainder of the immune system intact. In this article, we discuss our group’s experience in defining the parameters that impact the efficacy of β cell antigen “vaccination” for the prevention and treatment of T1D.

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Acknowledgments

This study was supported by a grant from the National Institutes of Health (R01AI05014). B.W. was supported by an ADA Career Development Award (1-04-CD-09).

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  1. Department of Microbiology and Immunology, University of North Carolina, Mary Ellen Jones Bldg., Room 635, Campus Box 7290, Chapel Hill, North Carolina, 27599-7290, USA

    Bo Wang & Roland Tisch

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  2. Roland Tisch
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Correspondence to Roland Tisch.

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Wang, B., Tisch, R. Parameters influencing antigen-specific immunotherapy for Type 1 diabetes. Immunol Res 42, 246–258 (2008). https://doi.org/10.1007/s12026-008-8090-5

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  • DOI: https://doi.org/10.1007/s12026-008-8090-5

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