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Progenitor migration to the thymus and T cell lineage commitment

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Abstract

T cells developing in the thymus are ultimately derived from bone marrow (BM) hematopoietic stem cells (HSCs). An understanding of the developmental steps between HSCs and T cells is important for gaining insight into cancers of the T lineage, improving T cell reconstitution after BM transplantation, and also to help ameliorate immunological defects in aging. In this article, we summarize our current understanding of the inter-related fields of early T cell development and thymic aging, and briefly discuss major unresolved questions in this field.

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Acknowledgments

This work was supported by grants from the NIH (AB). AB is also the recipient of a Leukemia and Lymphoma Society Scholar Award. JJB is supported by an institutional training grant from the NCI.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    Arivazhagan Sambandam, J. Jeremiah Bell, Benjamin A. Schwarz, Valerie P. Zediak, Anthony W. Chi, Daniel A. Zlotoff, Shanthi Lakshmi Krishnamoorthy, Jennifer M. Burg & Avinash Bhandoola

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  1. Arivazhagan Sambandam
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  2. J. Jeremiah Bell
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  3. Benjamin A. Schwarz
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  4. Valerie P. Zediak
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  5. Anthony W. Chi
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  6. Daniel A. Zlotoff
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  9. Avinash Bhandoola
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Correspondence to Avinash Bhandoola.

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Sambandam, A., Bell, J.J., Schwarz, B.A. et al. Progenitor migration to the thymus and T cell lineage commitment. Immunol Res 42, 65–74 (2008). https://doi.org/10.1007/s12026-008-8035-z

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