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Characterization of splenic CD21hi T2 B cells

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Abstract

B cell development is a highly regulated process that initiates in the bone marrow (BM) of adult mice. After reaching the IgM+ immature stage in the BM, these B cells migrate to the spleen to complete maturation and incorporation into the long-lived peripheral lymphocyte pool. Studies have identified these splenic immature B cells, and have further attempted to delineate the sequence whereby they transition into mature B cells. As such, these immature splenic populations are termed transitional B cells and have been the focus of intense study. The review summarizes the phenotype and currently known functions of the four putative transitional B cell subsets identified to date. Although most appear to represent short-lived transitional B cells, the CD21hi T2 B cell population exhibits a number of qualities that question its label as a transitional B cell subset.

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Acknowledgments

The authors wish to acknowledge the technical assistance of Teresa Duling, Gene Hess and Lorraine Tygrett, and the contribution of autoimmune mice by Dr. Polly Ferguson.

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Authors and Affiliations

  1. Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA

    Shilpi Verma & Thomas J. Waldschmidt

  2. Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA

    Thomas J. Waldschmidt

  3. 1038 Medical Laboratories, University of Iowa, Iowa City, IA, 52242, USA

    Thomas J. Waldschmidt

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  1. Shilpi Verma
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  2. Thomas J. Waldschmidt
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Correspondence to Thomas J. Waldschmidt.

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Verma, S., Waldschmidt, T.J. Characterization of splenic CD21hi T2 B cells. Immunol Res 39, 240–248 (2007). https://doi.org/10.1007/s12026-007-0072-5

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  • DOI: https://doi.org/10.1007/s12026-007-0072-5

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