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Inherited human IRAK-4 deficiency: an update

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Abstract

Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.

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Acknowledgments

We would like to thank Laurent Abel and all the members of our laboratory for helpful discussions and for critical reading of this text, and our collaborators at Necker and worldwide for their trust and patience over the years, in particular RA. Good, NK. Day, A. Ozinsky, X. Li, SN. Vogel, JI. Gallin, SM Holland, D. Lammas, G. Davies, H. Chapel, S. Al Hajjar, I. Zaid Al Moshen, D. Davidson, D. Speert, C. Roifman, A. Issekutz, C. Rodriguez-Gallego, L. Marodi, B. Zion Garty, K. Schwarz, S. Ehl, H. Takada, T. Hara, J. Smart, M. Tang, O. Levy, R. Geha, CK. Cunningham, X. Bossyut, F. Barrat and RL. Coffman. Needless to say, we are much indebted to the patients and their families. HvB was supported by grants from the Deutsche Forschungsgemeinschaft, Bonn, Germany (DFG n°-995/1 and -995/2). This work was supported by the Fondation BNP-Paribas, the Fondation Schlumberger, and EU grant number QLK2-CT-2002–00846. JLC is an International Scholar of the Howard Hughes Medical Institute.

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Authors and Affiliations

  1. Centre d’étude des déficits immunitaires, Hôpital Necker-Enfants Malades, 149 Rue de Sèvres, Paris, 75015, France, EU

    Capucine Picard

  2. Laboratoire de Génétique Humaine des Maladies Infectieuses, Institut National de la Santé et de la Recherche Médicale, U550, Paris, 75015, France, EU

    Capucine Picard

  3. Université Paris Descentes, Faculte Médecine Necker, Paris, France, EU

    Capucine Picard, Horst von Bernuth, Cheng-Lung Ku, Kun Yang, Anne Puel & Jean-Laurent Casanova

  4. Unité d’Immunologie et d’Hématologie Pédiatriques, Hôpital Necker-Enfants Malades, 149 Rue de Sèvres, Paris, 75015, France, EU

    Jean-Laurent Casanova

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  1. Capucine Picard
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  2. Horst von Bernuth
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  3. Cheng-Lung Ku
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  4. Kun Yang
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  5. Anne Puel
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  6. Jean-Laurent Casanova
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Correspondence to Capucine Picard.

Additional information

Presented at the First Robert A Good Society Symposium, St. Petersburg, FL 2006.

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Picard, C., von Bernuth, H., Ku, CL. et al. Inherited human IRAK-4 deficiency: an update. Immunol Res 38, 347–352 (2007). https://doi.org/10.1007/s12026-007-0006-2

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  • DOI: https://doi.org/10.1007/s12026-007-0006-2

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