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Another suicide by sodium nitrite and multiple drugs: an alarming trend for “exit”?

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Abstract

This case report describes a fatal case of sodium nitrite and multiple drug consumption. A 37-year-old female was found in bed with a plastic bottle containing sodium nitrite and a bag containing multiple drugs and a suicide note. The results of the autopsy showed completely fixed grayish livor mortis, signs of asphyxia on the lips, and facial cyanosis. This represents the second case in just a few months and highlights how relatively easy it is to buy sodium nitrite to commit suicide, indicating that specific responses should focus on restricting its access, especially in large quantities. It was also evident that the number of web forums and shadow markets explaining how to use sodium nitrite for euthanasia (several times called the “exit”) are increasing.

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References

  1. Chui JS, Poon WT, Chan KC, Chan AY, Buckley TA. Nitrite-induced methaemoglobinaemia - aetiology, diagnosis and treatment. Anaesthesia. 2005;60:496–500.

    Article  CAS  Google Scholar 

  2. Kalaycioglu Z, Erim FB. Nitrate and nitrites in foods: worldwide regional distribution in view of their risks and benefits. J Agric Food Chem. 2019;67:7205–22.

    Article  Google Scholar 

  3. Farkas AN, Scoccimarro A, Pizon AF. Methemoglobinemia due to antifreeze ingestion. N Engl J Med. 2017;377:1993–4.

    Article  Google Scholar 

  4. Bebarta VS, Brittain M, Chan A, Garrett N, Yoon D, Burney T, et al. Sodium nitrite and sodium thiosulfate are effective against acute cyanide poisoning when administered by intramuscular injection. Ann Emerg Med. 2017;69:718–25.e4.

  5. Harvey M, Cave G, Chanwai G. Fatal methaemoglobinaemia induced by self-poisoning with sodium nitrite. Emerg Med Australas. 2010;22:463–5.

    Article  Google Scholar 

  6. Saito T, Takeichi S, Yukawa N, Osawa M. Fatal methemoglobinemia caused by liniment solutions containing sodium nitrite. J Forensic Sci. 1996;41:169–71.

    Article  CAS  Google Scholar 

  7. Saito T, Takeichi S, Osawa M, Yukawa N, Huang XL. A case of fatal methemoglobinemia of unknown origin but presumably due to ingestion of nitrate. Int J Legal Med. 2000;113:164–7.

    Article  CAS  Google Scholar 

  8. Ellis M, Hiss Y, Shenkman L. Fatal methemoglobinemia caused by inadvertent contamination of a laxative solution with sodium nitrite. Isr J Med Sci. 1992;28:289–91.

    CAS  PubMed  Google Scholar 

  9. Cvetkovic D, Zivkovic V, Lukic V, Nikolic S. Sodium nitrite food poisoning in one family. Forensic Sci Med Pathol. 2019;15:102–5.

    Article  CAS  Google Scholar 

  10. Petroczi A, Naughton DP. Potentially fatal new trend in performance enhancement: a cautionary note on nitrite. J Int Soc Sports Nutr. 2010;7:25.

    Article  Google Scholar 

  11. Neth MR, Love JS, Zane Horowitz B, Shertz MD, Sahni R, Daya MR. Fatal sodium nitrite poisoning: key considerations for prehospital providers. Prehosp Emerg Care. 2020;1-10.

  12. Reade MC, Davies SR, Morley PT, Dennett J, Jacobs IC. Review article: management of cyanide poisoning. Emerg Med Australas. 2012;24:225–38.

    Article  Google Scholar 

  13. Mudan A, Repplinger D, Lebin J, Lewis J, Vohra R, Smollin C. Severe methemoglobinemia and death from intentional sodium nitrite ingestions. J Emerg Med. 2020;59:e85–8.

    Article  Google Scholar 

  14. Nitschke P, Stewart F. The peaceful pill handbook. Blaine: Exit International USA; 2019.

    Google Scholar 

  15. Durão C, Pedrosa F, Dinis-Oliveira RJ. A fatal case by a suicide kit containing sodium nitrite ordered on the internet. J Forensic Leg Med. 2020;73:101989.

    Article  Google Scholar 

  16. Park MJ, Kim O, Ha H. Death by nitrite intoxication: report of 14 cases. Korean J Leg Med. 2020;44:96–101.

    Article  Google Scholar 

  17. Cozanitis D, Asantila R, Eklund P, Paloheimo M. A comparison of ranitidine, droperidol or placebo in the prevention of nausea and vomiting after hysterectomy. Can J Anaesth. 1996;43:106–9.

    Article  CAS  Google Scholar 

  18. Patanwala AE, Amini R, Hays DP, Rosen P. Antiemetic therapy for nausea and vomiting in the emergency department. J Emerg Med. 2010;39:330–6.

    Article  Google Scholar 

  19. Brafford MV, Glode A. Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting. J Adv Prac Oncol. 2014;5:24–9.

    Google Scholar 

  20. Bailey JC, Feelisch M, Horowitz JD, Frenneaux MP, Madhani M. Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation. Pharmacol Ther. 2014;144:303–20.

    Article  CAS  Google Scholar 

  21. Bradberry SM, Whittington RM, Parry DA, Vale JA. Fatal methemoglobinemia due to inhalation of isobutyl nitrite. J Toxicol Clin Toxicol. 1994;32:179–84.

    Article  CAS  Google Scholar 

  22. O’Toole JB 3rd, Robbins GB, Dixon DS. Ingestion of isobutyl nitrite, a recreational chemical of abuse, causing fatal methemoglobinemia. J Forensic Sci. 1987;32:1811–2.

    Article  Google Scholar 

  23. Lefevre T, Nuzzo A, Mégarbane B. Poppers-induced life-threatening methemoglobinemia. Am J Respir Crit Care Med. 2018;198:e137–8.

    Article  CAS  Google Scholar 

  24. ACMT. Annual Scientific Meeting Abstracts – New York. NY J Med Toxicol. 2020;16:116–68.

    Article  Google Scholar 

  25. Standefer JC, Jones AM, Street E, Inserra R. Death associated with nitrite ingestion: report of a case. J Forensic Sci. 1979;24:768–71.

    CAS  PubMed  Google Scholar 

  26. Gowans WJ. Fatal methaemoglobinaemia in a dental nurse. A case of sodium nitrite poisoning. Br J Gen Pract. 1990;40:470–1.

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Price DP. Methemoglobin inducers. In: Nelson LS, Howland MA, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS, editors. Goldfrank’s toxicologic emergencies. 10th ed. New York: McGraw-Hill Education; 2019. pp. 1703–12.

  28. Piazza J, Douin C, Bodson L, Ghuysen A, D’Orio V. Blue baby syndrome: the source of the truth. Rev Med Liege. 2014;69:175–9.

    CAS  PubMed  Google Scholar 

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The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, and royalties.

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Correspondence to Ricardo Jorge Dinis-Oliveira.

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Durão, C., Pedrosa, F. & Dinis-Oliveira, R.J. Another suicide by sodium nitrite and multiple drugs: an alarming trend for “exit”?. Forensic Sci Med Pathol 17, 362–366 (2021). https://doi.org/10.1007/s12024-020-00340-2

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