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An interdisciplinary review of the thanatomicrobiome in human decomposition

Abstract

Death does not occur instantaneously and organs do not decompose at the same rate or in the same way. Nulligravid human uteri and prostate glands are the last internal organs to deteriorate during decomposition; however, the reason for this very important observation is still enigmatic. Recent studies have elucidated that the composition and abundance of microbes in the human thanatomicrobiome (microbiome of death) varies by organ and changes as a function of time and temperature. The ileocecal area has the largest absolute postmortem burden that spreads to the liver and spleen and continues to the heart and brain depending on the cause of death. To truly understand the mechanisms of microbial assembly during decomposition, a thorough examination of different strategies utilized by the trillions of microbes that colonize decaying tissues is needed from a multi-organ and multidisciplinary approach. In this review, we highlight interdisciplinary research and provide an overview of human decomposition investigations of thanatomicrobiomic changes in internal organs.

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Acknowledgements

This review paper was supported by National Science Foundation HRD 1401075 and National Institute of Justice 2017-MU-MU-0042 grants.

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Correspondence to Gulnaz T. Javan.

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The authors declare that no research involving human participants and/or animals was conducted in this review.

No identifying information about participants was used in this review.

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Javan, G.T., Finley, S.J., Tuomisto, S. et al. An interdisciplinary review of the thanatomicrobiome in human decomposition. Forensic Sci Med Pathol 15, 75–83 (2019). https://doi.org/10.1007/s12024-018-0061-0

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Keywords

  • Human decomposition
  • Internal organs
  • Thanatomicrobiome
  • Postmortem microbiome