Endocrine Pathology

, Volume 29, Issue 2, pp 137–149 | Cite as

Immunohistochemical Biomarkers of Adrenal Cortical Neoplasms

  • Ozgur Mete
  • Sylvia L. Asa
  • Thomas J. Giordano
  • Mauro Papotti
  • Hironobu Sasano
  • Marco Volante


Careful morphological evaluation forms the basis of the workup of an adrenal cortical neoplasm. However, the adoption of immunohistochemical biomarkers has added tremendous value to enhance diagnostic accuracy. The authors provide a brief review of immunohistochemical biomarkers that have been used in the confirmation of adrenal cortical origin and in the detection of the source of functional adrenal cortical proliferations, as well as diagnostic, predictive, and prognostic biomarkers of adrenal cortical carcinoma. In addition, a brief section on potential novel theranostic biomarkers in the prediction of treatment response to mitotane and other relevant chemotherapeutic agents is also provided. In the era of precision and personalized medical practice, adoption of combined morphology and immunohistochemistry provides a new approach to the diagnostic workup of adrenal cortical neoplasms, reflecting the evolution of clinical responsibility of pathologists.


Immunohistochemistry SF-1 CYP11B2 CYP11B1 IGF-2 Ki67 p53 Beta-catenin Mitotane Adrenal cortical carcinoma 



The authors would like to thank Dr. Celso E. Gomez-Sanchez for providing the CYP11B1/2 monoclonal antibody for immunohistochemistry and Dr. Masao Doi and Dr. Hitoshi Okamura for providing the HSD3B1/2 monoclonal antibody.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ozgur Mete
    • 1
  • Sylvia L. Asa
    • 1
  • Thomas J. Giordano
    • 2
  • Mauro Papotti
    • 3
  • Hironobu Sasano
    • 4
  • Marco Volante
    • 5
  1. 1.Department of PathologyUniversity Health NetworkTorontoCanada
  2. 2.Departments of Pathology and Internal MedicineUniversity of Michigan Health SystemAnn ArborUSA
  3. 3.Department of PathologyTurin University at Molinette HospitalTurinItaly
  4. 4.Department of PathologyTohoku University School of MedicineSendaiJapan
  5. 5.Department of Oncology, University of Turin at San Luigi HospitalTurin UniversityTurinItaly

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