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Different CXCR4 Expression According to Various Histologic Subtype of Papillary Thyroid Carcinoma

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Abstract

Functional chemokine (C-X-C motif) receptor 4 (CXCR4) is well known to be over-expressed in papillary thyroid carcinoma (PTC). The aim of this study was to evaluate whether or not the expression of CXCR4 is different by histological subtypes of PTC and to elucidate the relationship between the expression of CXCR4 and clinicopathologic factors. CXCR4 expression in 127 PTC samples was assessed using immunohistochemical staining. The expression of CXCR4 showed different patterns according to the histological subtype of PTC (p < 0.001). A strong expression of CXCR4 was observed more frequently in the poorly differentiated region of PTC (81.0 %) than in classical PTC (50.0 %). Strong CXCR4 expression was less frequently shown in follicular variant (33.9 %) and in diffuse sclerosing variant (14.3 %) of PTC. CXCR4 expression showed a distinct pattern according to the histological subtype of PTC although not associated with other clinicopathological parameters.

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Acknowledgments

This work was supported by Yonsei University College of Medicine faculty research grant 2010 (No. 6-2010-0137).

Conflict of interest

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

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Authors and Affiliations

  1. Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro Seodaemun-gu, Seoul, 120-752, South Korea

    Dong Yeob Shin, Kwang Joon Kim, Cheol Ryong Ku & Eun Jig Lee

  2. Severance Executive Healthcare Clinic, Yonsei University Health system, 50 Yonsei-ro Seodaemun-gu, Seoul, 120-752, South Korea

    Kwang Joon Kim

  3. Department of Pathology, NHIS Ilsan Hospital, 100 Ilsan-ro Ilsan-donggu, Goyang-si, Gyeonggi-do, 410-719, South Korea

    Mi Kyung Lee & Soo Il Jee

  4. Department of Surgery, Yonsei University College of Medicine, Seoul, 120-752, South Korea

    Woong Youn Chung

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  1. Dong Yeob Shin
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Correspondence to Eun Jig Lee.

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Shin, D.Y., Kim, K.J., Ku, C.R. et al. Different CXCR4 Expression According to Various Histologic Subtype of Papillary Thyroid Carcinoma. Endocr Pathol 24, 169–176 (2013). https://doi.org/10.1007/s12022-013-9259-6

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  • DOI: https://doi.org/10.1007/s12022-013-9259-6

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