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Metastatic Carcinoma to the Thyroid Gland: A Single Institution 20-Year Experience and Review of the Literature

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Abstract

The thyroid gland is an uncommon site for metastatic disease but cases have been well-documented in the literature, particularly in autopsy series. A retrospective review of surgical pathology and autopsy pathology database for patients with metastatic carcinoma to the thyroid was performed at the University of Massachusetts Medical Center between January 1993 to January 2013. We identified a total of 10 patients with metastatic carcinoma to the thyroid; 6 were in surgical pathology specimens out of a total of 1,295 thyroid carcinoma (0.46 %) and 4 were diagnosed at autopsy out of a total of 2,117 (0.19 %) autopsy cases during this period. Cases with direct extension of the tumor into the thyroid from local primary sites such as larynx, esophagus or soft tissues of the neck were excluded. The primary tumors in these cases comprised of four lung carcinomas, three colorectal carcinomas, a renal cell carcinoma, a pleural malignant mesothelioma, and an unknown primary. Therefore, it is important to keep intrathyroidal metastases in the differential diagnosis when evaluating a thyroid nodule, particularly in patients with a previous history of malignancy. Furthermore, a literature review reveals over 1,400 cases have been previously reported, with the most common malignancies from the kidney (34 %), lung (15 %), gastrointestinal tract (14 %), and breast (14 %).

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References

  1. Heffess CS, Wenig BM, Thompson LD. Metastatic renal cell carcinoma to the thyroid gland: a clinicopathologic study of 36 cases. Cancer 95(9):1869–1878, 2002.

    Article  PubMed  Google Scholar 

  2. Watanabe I, Tsuchiya A. Secondary carcinoma of the thyroid gland. The Japanese journal of surgery 10(2):130–136, 1980.

    Article  PubMed  CAS  Google Scholar 

  3. Nakhjavani MK, Gharib H, Goellner JR, van Heerden JA. Metastasis to the thyroid gland. A report of 43 cases. Cancer 79(3):574–578, 1997.

    Article  PubMed  CAS  Google Scholar 

  4. Lam KY, Lo CY. Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients. Arch Pathol Lab Med 122(1):37–41, 1998.

    PubMed  CAS  Google Scholar 

  5. Silverberg SG, Vidone RA. Carcinoma of the thyroid in surgical and postmortem material. Analysis of 300 cases at autopsy and literature review. Annals of surgery 164(2):291–299, 1966.

    Article  PubMed  CAS  Google Scholar 

  6. Abrams HL, Spiro R, Goldstein N. Metastases in carcinoma; analysis of 1000 autopsied cases. Cancer 3(1):74–85, 1950.

    Article  PubMed  CAS  Google Scholar 

  7. Shimaoka K, Sokal JE, Pickren JW. Metastatic neoplasms in the thyroid gland. Pathological and clinical findings. Cancer 15:557–565, 1962.

    Article  PubMed  CAS  Google Scholar 

  8. Perloff WH, Schneeberg NG: The problem of thyroid carcinoma. Surgery 29(4):572–580, 1951.

    PubMed  CAS  Google Scholar 

  9. Wood K, Vini L, Harmer C. Metastases to the thyroid gland: the Royal Marsden experience. European Journal of Surgical Oncology: The Journal of The European Society of Surgical Oncology and the British Association of Surgical Oncology 30(6):583–588, 2004.

    Article  CAS  Google Scholar 

  10. Menegaux F, Chigot JP. [Thyroid metastases]. Annales de chirurgie 126(10):981–984, 2001.

  11. Ishikawa M, Hirano S, Tsuji T, Ito J. Management of metastasis to the thyroid gland. Auris Nasus Larynx 38(3):426–430, 2011.

    Article  PubMed  Google Scholar 

  12. Wychulis AR, Beahrs OH, Woolner LB. Metastasis of carcinoma to the thyroid gland. Annals of surgery 160:169–177, 1964.

    Article  PubMed  CAS  Google Scholar 

  13. Lin JD, Weng HF, Ho YS. Clinical and pathological characteristics of secondary thyroid cancer. Thyroid: official journal of the American Thyroid Association 8(2):149–153, 1998.

    Article  CAS  Google Scholar 

  14. Gerges AS, Shehata SR, Gouda IA. Metastasis to the thyroid gland; unusual site of metastasis. Journal of the Egyptian National Cancer Institute 18(1):67–72, 2006.

    PubMed  CAS  Google Scholar 

  15. Cumbo-Nacheli G, de Sanctis JT, Chung MH. Proximal esophageal adenocarcinoma presenting as a thyroid mass: case report and review of the literature. Thyroid: official journal of the American Thyroid Association 17(3):267–269, 2007.

    Article  CAS  Google Scholar 

  16. Papi G, Fadda G, Corsello SM, Corrado S, Rossi ED, Radighieri E, Miraglia A, Carani C, Pontecorvi A. Metastases to the thyroid gland: prevalence, clinicopathological aspects and prognosis: a 10-year experience. Clinical endocrinology 66(4):565–571, 2007.

    PubMed  Google Scholar 

  17. Bayram F, Soyuer I, Atmaca H, Demirci D, Gokce C, Canoz O, Unluhizarci K, Kelestimur F. Prostatic adenocarcinoma metastasis in the thyroid gland. Endocrine journal 51(4):445–448, 2004.

    Article  PubMed  Google Scholar 

  18. Cope O, Dobyns BM, Hamlin Jr E, Hopkirk J. What thyroid nodules are to be feared? The Journal of Clinical Endocrinology & Metabolism 9(10): 1012–1022, 1949.

    Article  CAS  Google Scholar 

  19. Crabtree HN, Hunter DC, Jr. Carcinoma of the thyroid; a clinicopathologic study. AMA archives of surgery 67(2):175–186, 1953.

    Article  PubMed  CAS  Google Scholar 

  20. Basu S, Nair N, Borges AM. Squamous cell carcinoma of esophagus masquerading as solitary thyroid nodule. Indian journal of cancer 42(4):205–207, 2005.

    PubMed  CAS  Google Scholar 

  21. Butte JM, Marin L, Meneses M, De la Fuente H, Pruzzo R, Redondo F, Parada H, Amaral H, Waugh E. Thyroid metastases from gallbladder cancer. Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract 13(7):1389–1391, 2009.

    Article  Google Scholar 

  22. Chen H, Nicol TL, Udelsman R. Clinically significant, isolated metastatic disease to the thyroid gland. World journal of surgery 23(2):177–180; discussion 181, 1999.

    Google Scholar 

  23. Matias-Guiu X, LaGuette J, Puras-Gil AM, Rosai J. Metastatic neuroendocrine tumors to the thyroid gland mimicking medullary carcinoma: a pathologic and immunohistochemical study of six cases. Am J Surg Pathol 21(7):754–762, 1997.

    Article  PubMed  CAS  Google Scholar 

  24. Goatman C, Goldsmith PJ, Antonopoulos V, Ali B. Metastasis of colorectal adenocarcinoma to the thyroid: a case report and review of the literature. Case reports in surgery 2012:179407, 2012.

    Article  PubMed  CAS  Google Scholar 

  25. Kelly ME, Kinsella J, d'Adhemar C, Swan N, Ridgway PF. A rare case of thyroid metastasis from pancreatic adenocarcinoma. JOP: Journal of the pancreas 12(1):37–39, 2011.

    PubMed  CAS  Google Scholar 

  26. Fujita T, Ogasawara Y, Doihara H, Shimizu N. Rectal adenocarcinoma metastatic to the thyroid gland. International journal of clinical oncology 9(6):515–519, 2004.

    Article  PubMed  Google Scholar 

  27. Willis RA. Metastatic tumours in the thyreoid gland. Am J Pathol 7(3):187–208 183, 1931.

    Google Scholar 

  28. Nixon IJ, Whitcher M, Glick J, Palmer FL, Shaha AR, Shah JP, Patel SG, Ganly I. Surgical management of metastases to the thyroid gland. Annals of surgical oncology 18(3):800–804, 2011.

    Article  PubMed  Google Scholar 

  29. Park MH, Cho JS, Lee JS, Kim HK, Yoon JH. Thyroid gland metastasis arising from primary liver cholangiocarcinoma: the first case report involving surgical operation. International journal of surgery case reports 3(2):78–81, 2012.

    Article  PubMed  Google Scholar 

  30. Lacka K, Breborowicz D, Uliasz A, Teresiak M. Thyroid metastases from a breast cancer diagnosed by fine-needle aspiration biopsy. Case report and overview of the literature. Experimental oncology 34(2):129–133, 2012.

    PubMed  CAS  Google Scholar 

  31. McCabe DP, Farrar WB, Petkov TM, Finkelmeier W, O'Dwyer P, James A. Clinical and pathologic correlations in disease metastatic to the thyroid gland. American journal of surgery 150(4):519–523, 1985.

    Article  PubMed  CAS  Google Scholar 

  32. Kim TY, Kim WB, Gong G, Hong SJ, Shong YK. Metastasis to the thyroid diagnosed by fine-needle aspiration biopsy. Clinical endocrinology 62(2):236–241, 2005.

    Article  PubMed  Google Scholar 

  33. Jankowska P, Teoh EM, Fisher C, Rhys Evans P, Nutting CM, Harrington KJ. Case report. Isolated intrathyroid metastasis from undifferentiated and squamous carcinoma of the head and neck: the case for surgery and re-irradiation. Br J Radiol 81(966):e154-161, 2008.

    Article  PubMed  CAS  Google Scholar 

  34. Mirallie E, Rigaud J, Mathonnet M, Gibelin H, Regenet N, Hamy A, Bretagnol F, de Calan L, Le Neel JC, Kraimps JL. Management and prognosis of metastases to the thyroid gland. Journal of the American College of Surgeons 200(2):203–207, 2005.

    Article  PubMed  Google Scholar 

  35. Ivy HK. Cancer metastatic to the thyroid: a diagnostic problem. Mayo Clinic proceedings Mayo Clinic 59(12):856–859, 1984.

    Article  PubMed  CAS  Google Scholar 

  36. Tsou PL, Chang TC. Ultrasonographic and cytologic findings of metastatic cancer in the thyroid gland. Journal of the Formosan Medical Association = Taiwan yi zhi 100(2):106–112, 2001

    PubMed  CAS  Google Scholar 

  37. Calzolari F, Sartori PV, Talarico C, Parmeggiani D, Beretta E, Pezzullo L, Bovo G, Sperlongano P, Monacelli M, Lucchini R et al. Surgical treatment of intrathyroid metastases: preliminary results of a multicentric study. Anticancer research 28(5B):2885–2888, 2008.

    PubMed  Google Scholar 

  38. Wada N, Hirakawa S, Rino Y, Hasuo K, Kawachi K, Nakatani Y, Inui K, Takanashi Y. Solitary metachronous metastasis to the thyroid from renal clear cell carcinoma 19 years after nephrectomy: report of a case. Surgery today 35(6):483–487, 2005.

    Article  PubMed  Google Scholar 

  39. Janser JC, Rodier C, Pusel J, Rodier D. [Intrathyroidal metastases of a nephroepithelioma. Reflections on 5 operated cases]. Journal de chirurgie 123(10):574–577, 1986.

    PubMed  CAS  Google Scholar 

  40. Valo I, Verriele V, Giraud P, Lorimier G, Guyetant S, Sommelet D. [Thyroid metastases of an adrenocortical carcinoma 41 years after the diagnosis of the primary tumor]. Annales de pathologie 24(3):264–267, 2004.

    Article  PubMed  Google Scholar 

  41. Hashimoto K, Yamamoto H, Nakano T, Oyama M, Shiratsuchi H, Nakashima T, Tamiya S, Komune S, Oda Y. Tumor-to-tumor metastasis: lung adenocarcinoma metastasizing to a follicular variant of papillary thyroid carcinoma. Pathology international 61(7):435–441, 2011.

    Article  PubMed  CAS  Google Scholar 

  42. Bae WK, Shim HJ, Choi YD, Kim JW, Cho SH, Kang HC, Chung IJ. Severe hypothyroidism induced by thyroid metastasis of cholangiocarcinoma. Cancer research and treatment: official journal of Korean Cancer Association 41(1):56–58, 2009.

    Article  Google Scholar 

  43. Miyakawa M, Sato K, Hasegawa M, Nagai A, Sawada T, Tsushima T, Takano K. Severe thyrotoxicosis induced by thyroid metastasis of lung adenocarcinoma: a case report and review of the literature. Thyroid: official journal of the American Thyroid Association 11(9):883–888, 2001.

    Article  CAS  Google Scholar 

  44. Li B, Tang Y, Xiao D, Zhong M. Coexistence of thyroid metastasis carcinoma in the background of HT and primary thyroid mucosa-associated lymphoid tissue B cell lymphoma in a thyroid gland. Annals of hematology 89(10):1053–1056, 2010.

    Article  PubMed  Google Scholar 

  45. Eriksson M, Ajmani SK, Mallette LE. Hyperthyroidism from thyroid metastasis of pancreatic adenocarcinoma. JAMA: the journal of the American Medical Association 238(12):1276–1278, 1977.

    Article  CAS  Google Scholar 

  46. De Ridder M, Sermeus AB, Urbain D, Storme GA. Metastases to the thyroid gland-a report of six cases. European journal of internal medicine 14(6):377–379, 2003.

    Article  PubMed  Google Scholar 

  47. Youn JC, Rhee Y, Park SY, Kim WH, Kim SJ, Chung HC, Hong SW, Lim SK. Severe hypothyroidism induced by thyroid metastasis of colon adenocarcinoma: a case report and review of the literature. Endocrine journal 53(3):339–343, 2006.

    Article  PubMed  Google Scholar 

  48. Cihan YB, Deniz K, Yilmaz MS. Synchronous parotid and thyroid gland metastases from breast cancer. Breast care 6(2):133–135, 2011.

    Article  PubMed  Google Scholar 

  49. Giorgadze T, Ward RM, Baloch ZW, LiVolsi VA. Phyllodes tumor metastatic to thyroid Hurthle cell adenoma. Arch Pathol Lab Med 126(10):1233–1236, 2002.

    PubMed  Google Scholar 

  50. Cozzolino I, Malapelle U, Carlomagno C, Palombini L, Troncone G. Metastasis of colon cancer to the thyroid gland: a case diagnosed on fine-needle aspirate by a combined cytological, immunocytochemical, and molecular approach. Diagnostic cytopathology 38(12):932–935, 2010.

    Article  PubMed  Google Scholar 

  51. Owens CL, Basaria S, Nicol TL. Metastatic breast carcinoma involving the thyroid gland diagnosed by fine-needle aspiration: a case report. Diagnostic cytopathology 33(2):110–115, 2005.

    Article  PubMed  Google Scholar 

  52. De Stefano R, Carluccio R, Zanni E, Marchiori D, Cicchetti G, Bertaccini A, Sensi L, Pedrini L, Martorana G, Marlia E. Management of thyroid nodules as secondary involvement of renal cell carcinoma: case report and literature review. Anticancer research 29(2):473–476, 2009.

    PubMed  Google Scholar 

  53. Watts NB. Carcinoma metastatic to the thyroid: prevalence and diagnosis by fine-needle aspiration cytology. The American journal of the medical sciences 293(1):13–17, 1987.

    Article  PubMed  CAS  Google Scholar 

  54. Michelow PM, Leiman G. Metastases to the thyroid gland: diagnosis by aspiration cytology. Diagnostic cytopathology 13(3):209–213, 1995.

    Article  PubMed  CAS  Google Scholar 

  55. Rosen IB, Walfish PG, Bain J, Bedard YC. Secondary malignancy of the thyroid gland and its management. Annals of surgical oncology 2(3):252–256, 1995.

    Article  PubMed  CAS  Google Scholar 

  56. Chung SY, Kim EK, Kim JH, Oh KK, Kim DJ, Lee YH, An HJ, Kim JS. Sonographic findings of metastatic disease to the thyroid. Yonsei medical journal 42(4):411–417, 2001.

    PubMed  CAS  Google Scholar 

  57. Halbauer M, Kardum-Skelin I, Vranesic D, Crepinko I. Aspiration cytology of renal-cell carcinoma metastatic to the thyroid. Acta cytologica 35(4):443–446, 1991.

    PubMed  CAS  Google Scholar 

  58. Sant F, Moysset I, Badal JM, Aliart M, Lloreta J. Fine-needle aspiration of chromophobe renal-cell carcinoma metastatic to the thyroid gland. Diagnostic cytopathology 24(3):193–194, 2001.

    Article  PubMed  CAS  Google Scholar 

  59. Castillo Morales V, Garcia Alonso P, Balsa Breton MA, Ortega Valle A, Penin Gonzalez J, Pey Illera C. Pancreatic and thyroid metastases detected with 18F-FDG PET/CT in patient with colorectal cancer. Revista espanola de medicina nuclear e imagen molecular 31(6):335–337, 2012.

    PubMed  CAS  Google Scholar 

  60. Toshima T, Taketomi A, Shirabe K, Takeishi K, Motomura T, Mano Y, Morita K, Fukuhara T, Sugimachi K, Maruoka Y et al. Solitary asymptomatic thyroid metastasis from hepatocellular carcinoma detected by FDG-PET/CT. Case reports in gastroenterology 4(2):279–285, 2010.

    Article  PubMed  Google Scholar 

  61. Basu S, Alavi A. Metastatic malignant melanoma to the thyroid gland detected by FDG-PET imaging. Clinical nuclear medicine 32(5):388–389, 2007.

    Article  PubMed  Google Scholar 

  62. Wolf G, Aigner RM, Schwarz T, Nicoletti R. [Diagnosis of metastasis of malignant melanoma in the thyroid gland with f18-FDG PET scan]. Hautarzt 53(5):332–333, 2002.

    Article  PubMed  CAS  Google Scholar 

  63. Kaushik A, Ho L. Thyroid metastasis from primary renal cell cancer on FDG PET/CT. Clinical nuclear medicine 36(1):56–58, 2011.

    Article  PubMed  Google Scholar 

  64. Manohar K, Mittal BR, Kashyap R, Bhattacharya A, Singh B. Renal cell carcinoma presenting as isolated thyroid metastasis 13 years after radical nephrectomy, detected on F-18 FDG PET/CT. Clinical nuclear medicine 35(10):818–819, 2010.

    Article  PubMed  Google Scholar 

  65. Iguchi T, Matsuoka J, Sato S, Okumura Y, Omori M, Mifune H, Akaki S, Kanazawa S. F-18 FDG PET demonstration of a thyroid metastasis in a patient with colon cancer. Clinical nuclear medicine 32(5):361–362, 2007.

    Article  PubMed  Google Scholar 

  66. Smith SA, Gharib H, Goellner JR. Fine-needle aspiration. Usefulness for diagnosis and management of metastatic carcinoma to the thyroid. Archives of internal medicine 147(2):311–312, 1987.

    Article  PubMed  CAS  Google Scholar 

  67. Cichon S, Anielski R, Konturek A, Barczynski M, Cichon W. Metastases to the thyroid gland: seventeen cases operated on in a single clinical center. Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie 391(6):581–587, 2006.

    Article  PubMed  Google Scholar 

  68. Harcourt-Webster JN. Secondary neoplasm of the thyroid presenting as a goitre. Journal of clinical pathology 18:282–287, 1965.

    Article  PubMed  CAS  Google Scholar 

  69. Ericsson M, Biorklund A, Cederquist E, Ingemansson S, Akerman M. Surgical treatment of metastatic disease in the thyroid gland. J Surg Oncol 17(1):15–23, 1981.

    Article  PubMed  CAS  Google Scholar 

  70. Mortensen J, Woolner LB, Bennett WA. Secondary malignant tumors of the thyroid gland. Cancer 9(2):306–309, 1956.

    Article  PubMed  CAS  Google Scholar 

  71. Pillay SP, Angorn IB, Baker LW. Tumour metastasis to the thyroid gland. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 51(15):509–512, 1977

    PubMed  CAS  Google Scholar 

  72. Chung AY, Tran TB, Brumund KT, Weisman RA, Bouvet M. Metastases to the thyroid: a review of the literature from the last decade. Thyroid: official journal of the American Thyroid Association 22(3):258–268, 2012.

    Article  Google Scholar 

  73. Robinson BW, Musk AW, Lake RA: Malignant mesothelioma. Lancet 366(9483):397–408, 2005.

    Article  PubMed  CAS  Google Scholar 

  74. Soyuer I, Soyuer S, Canoz O, Coskun S, Balkanli S. Educational case report—self-assessment. Three patients with unusual metastases. Cytopathology: official journal of the British Society for Clinical Cytology 15(1):2, 58–62, 2004.

    Google Scholar 

  75. Schmid KW, Hittmair A, Ofner C, Totsch M, Ladurner D. Metastatic tumors in fine needle aspiration biopsy of the thyroid. Acta cytologica 35(6):722–724, 1991.

    PubMed  CAS  Google Scholar 

  76. Stevens TM, Richards AT, Bewtra C, Sharma P. Tumors metastatic to thyroid neoplasms: a case report and review of the literature. Pathology research international 2011 238693, 2011.

    Article  PubMed  Google Scholar 

  77. Fadare O, Parkash V, Fiedler PN, Mayerson AB, Asiyanbola B. Tumor-to-tumor metastasis to a thyroid follicular adenoma as the initial presentation of a colonic adenocarcinoma. Pathology international 55(9):574–579, 2005.

    Article  PubMed  Google Scholar 

  78. Baloch ZW, LiVolsi VA. Tumor-to-tumor metastasis to follicular variant of papillary carcinoma of thyroid. Arch Pathol Lab Med 123(8):703–706, 1999.

    PubMed  CAS  Google Scholar 

  79. Yu J, Nikiforova MN, Hodak SP, Yim JH, Cai G, Walls A, Nikiforov YE, Seethala RR. Tumor-to-tumor metastases to follicular variant of papillary thyroid carcinoma: histologic, immunohistochemical, and molecular studies of two unusual cases. Endocrine pathology 20(4):235–242, 2009.

    Article  PubMed  Google Scholar 

  80. Kameyama K, Kamio N, Okita H, Hata J. Metastatic carcinoma in follicular adenoma of the thyroid gland. Pathol Res Pract 196(5):333–336; discussion 337–338, 2000.

    Google Scholar 

  81. Bohn OL, De las Casas LE, Leon ME. Tumor-to-tumor metastasis: Renal cell carcinoma metastatic to papillary carcinoma of thyroid-report of a case and review of the literature. Head and neck pathology 3(4):327–330, 2009.

    Article  PubMed  Google Scholar 

  82. Dobbing J. Cancer to cancer. Guy's Hospital reports 107(1):60–65, 1958.

    PubMed  CAS  Google Scholar 

  83. Campbell LV, Jr., Gilbert E, Chamberlain CR, Jr., Watne AL. Metastases of cancer to cancer. Cancer 22(3):635–643, 1968.

    Article  PubMed  Google Scholar 

  84. Cherk MH, Moore M, Serpell J, Swain S, Topliss DJ. Metastatic colorectal cancer to a primary thyroid cancer. World journal of surgical oncology 6:122, 2008.

    Article  PubMed  Google Scholar 

  85. Chiumento C, Fiorentino A, Castaldo G, Fusco V. A case of thyroid metastasis of nasopharyngeal cancer. Tumori 97(5):24e-26e, 2011.

    PubMed  Google Scholar 

  86. Karapanagiotou E, Saif MW, Rondoyianni D, Markaki S, Alamara C, Kiagia M, Pantazopoulos K, Tzannou I, Syrigos K. Metastatic cervical carcinoma to the thyroid gland: a case report and review of the literature. The Yale journal of biology and medicine 79(3–4):165–168, 2006.

    PubMed  Google Scholar 

  87. Lee HC, Chen FF, Lo CC, Wang CJ, Lo WC, Luh SP. Metastasis of gastric carcinoma to the thyroid and lung: a case report and review of literature. Journal of Zhejiang University Science B 11(7):542–546, 2010.

    Article  PubMed  Google Scholar 

  88. Machens A, Dralle H. Outcome after thyroid surgery for metastasis from renal cell cancer. Surgery 147(1):65–71, 2010.

    Article  PubMed  Google Scholar 

  89. Palazzo FF, Bradpiece HA, Morgan MW. Renal cell carcinoma metastasizing to the thyroid gland. Scandinavian journal of urology and nephrology 33(3):202–204, 1999.

    Article  PubMed  CAS  Google Scholar 

  90. Iesalnieks I, Winter H, Bareck E, Sotiropoulos GC, Goretzki PE, Klinkhammer-Schalke M, Brockner S, Trupka A, Anthuber M, Rupprecht H et al. Thyroid metastases of renal cell carcinoma: clinical course in 45 patients undergoing surgery. Assessment of factors affecting patients' survival. Thyroid: official journal of the American Thyroid Association 18(6):615–624, 2008.

    Article  Google Scholar 

  91. Lievre A, Leboulleux S, Boige V, Travagli JP, Dromain C, Elias D, Ducreux M, Malka D. Thyroid metastases from colorectal cancer: the Institut Gustave Roussy experience. European journal of cancer 42(12):1756–1759, 2006.

    Article  PubMed  Google Scholar 

  92. Azevedo CR, Cezana L, Moraes ES, Begnami MD, Paiva Junior TF, Dettino AL, Fanelli MF. Synchronous thyroid and colon metastases from epidermoid carcinoma of the lung: case report. Sao Paulo medical journal = Revista paulista de medicina 128(6):371–374, 2010

    PubMed  Google Scholar 

  93. Seki H, Ueda T, Shibata Y, Sato Y, Yagihashi N. Solitary thyroid metastasis of renal clear cell carcinoma: report of a case. Surgery today 31(3):225–229, 2001.

    Article  PubMed  CAS  Google Scholar 

  94. Dionigi G, Uccella S, Gandolfo M, Lai A, Bertocchi V, Rovera F, Tanda ML. Solitary intrathyroidal metastasis of renal clear cell carcinoma in a toxic substernal multinodular goiter. Thyroid research 1(1):6, 2008.

    Article  PubMed  Google Scholar 

  95. Czech JM, Lichtor TR, Carney JA, van Heerden JA. Neoplasms metastatic to the thyroid gland. Surgery, gynecology & obstetrics 155(4):503–505, 1982.

    CAS  Google Scholar 

  96. Hacker U, Lenz G, Brehm G, Muller-Hocker J, Schalhorn A, Hiddemann W. Metastasis of a rectal adenocarcinoma to the thyroid gland: diagnostic and therapeutic implications. Anticancer research 23(6D):4973–4976, 2003.

    PubMed  Google Scholar 

  97. Kjaer M. The treatment and prognosis of patients with renal adenocarcinoma with solitary metastasis. 10 year survival results. International journal of radiation oncology, biology, physics 13(4):619–621, 1987.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Pathology, University of Massachusetts Medical School, Biotech 3, One Innovation Drive, Worcester, MA, 01605, USA

    Parnian Ahmadi Moghaddam, Kristine M. Cornejo & Ashraf Khan

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  1. Parnian Ahmadi Moghaddam
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Parnian Ahmadi Moghaddam and Kristine M. Cornejo contributed equally to this study and are considered as co-first authors.

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Moghaddam, P.A., Cornejo, K.M. & Khan, A. Metastatic Carcinoma to the Thyroid Gland: A Single Institution 20-Year Experience and Review of the Literature. Endocr Pathol 24, 116–124 (2013). https://doi.org/10.1007/s12022-013-9257-8

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