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Increasing Diagnosis of Thyroid Papillary Carcinoma Follicular Variant in South-East Anatolian Region: Comparison of Characteristics of Classical Papillary and Follicular Variant Thyroid Cancers

Endocrine Pathology volume 23, pages 157–160 (2012)Cite this article

Abstract

We aimed to compare ratios of thyroid cancers diagnosed in our regional reference hospital Pathology Center in Sanliurfa city located in southeast Anatolia, and evaluate the characteristics related with follicular variant papillary thyroid carcinoma (FVPTC). We re-evaluated the specimens of last 5 years thyroidectomies by same five pathologists, by same criteria and immunohistochemical evaluation. Chi-square test was used to compare characteristics of classical pure papillary thyroid carcinomas and FVPTC groups. Stepwise multiple regression analysis was used to evaluate the factors related with presence of FVPTC. Among 400 thyroidectomies, there were 105 papillary thyroid carcinoma, 42 of them with pure PTC, and 56 with FVPC, also seven with other variants. There was increase in ratios of FVPTC/PTC between 2010 and 2011 (68.4 vs 76.7 %, p < 0.005). Radius, vascular invasion, and extrathyroidal invasion showed statistically significant difference between pure PTC and FVPTC. In regression analysis radius (p = 0.001, OR = 2.611; 95 %CI, 2.010–3.391), age (p = 0.018, OR = 0.959; 95 %CI, 0.927–0.993), and multicentricity (p = 0.044, OR = 0.403; 95 %CI, 0.167–0.975) were related with presence of FVPTC. Besides, further need for studies to understand whether total prevalence of FVPTC is higher in this region, and the related factors, our study showed that the ratio of FVPTC/PTC is higher in our reference hospital. Age of the patients and the radius and multicentricity of the nodules could be alarming factors for us to suspect for FVPTC.

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References

  1. Gosnell JE, Clark OH. Surgical approaches to thyroid tumors. Endocrinol Metab Clin North Am 2008;37:437e55.

    Article  Google Scholar 

  2. Hundahl SA, CadyB, CunninghamMP,etal.Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the United States during 1996.U.S.and German Thyroid Cancer Study Group.Cancer 2000;89: 202e17

    Article  Google Scholar 

  3. Schlumberger MJ. Papillary and follicular thyroid carcinoma. N Eng J Med 2004;338:297–306

    Article  Google Scholar 

  4. Passler C, Prager G, Scheuba C, et al. Follicular variant of papillary thyroid carcinoma: a long-term follow-up. Arch Surg 2003;138:1362–1366

    PubMed  Article  Google Scholar 

  5. Tielens ET, Sherman SI, Hruban RH, et al. Follicular variant of papillary thyroid carcinoma. A clinicopathologic study. Cancer 1994;73:424–431

    PubMed  Article  CAS  Google Scholar 

  6. Sebastian SO, Gonzalez JM, Paricio PP, et al. Papillary thyroid carcinoma:prognostic index for survival including the histological variety. Arch Surg 2000;135:272–277

    PubMed  Article  CAS  Google Scholar 

  7. Carcangiu ML, Zampi G, Pupi A, et al. Papillary carcinoma of the thyroid. A clinicopathologic study of 241 cases treated at the University of Florence, Italy. Cancer 1985;55:805–828

    PubMed  Article  CAS  Google Scholar 

  8. Chan JK. Strict criteria should be applied in the diagnosis of encapsulated follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 2002;117:16–18

    PubMed  Article  Google Scholar 

  9. Chang HY, Lin JD, Chou SC, Chao TC, Hsueh C. Clinical presentations and outcomes of surgical treatment of follicular variant of the papillary thyroid carcinomas. Jpn J Clin Oncol 2006;36:688–693

    PubMed  Article  Google Scholar 

  10. Igci YZ, Arslan A, Akarsu E, et al. Different expression of a set of genes in follicular and classical variant of papillary thyroid carcinoma. Endocr Pathol 2011;22:86–96

    PubMed  Article  Google Scholar 

  11. Kim DS, Kim JH, Na DG, et al. Sonographic features of follicular variant papillary thyroid carcinomas in comparison with conventional papillary thyroid carcinomas. J Ultrasound Med 2009;28:1685–1692

    PubMed  Google Scholar 

  12. Yoon JH, Kim EK, Hong SW, Kwak JY, Kim MJ. Sonographic features of the follicular variant of papillary thyroid carcinoma. J Ultrasound Med 2008;27:1431–1437

    PubMed  Google Scholar 

  13. Lin HW, Bhattacharyya N. Clinical behaviour of follicular variant of papillary thyroid carcinoma: presentation and survival. Laryngoscope 2010;120:712–716

    PubMed  Article  Google Scholar 

  14. Liu J, Singh B, Tallini G, et al. Follicular variant of papillary carcinoma: a clinicopathologic study of a problematic entity. Cancer 2006;107:1255–1264

    PubMed  Article  Google Scholar 

  15. Erdogan MF, Agbaht K, Altinsu T, et al. Current iodine status in Turkey. J Endocrinol Invest 2009;32:617–622

    PubMed  CAS  Google Scholar 

  16. Burningham AR, Krishnan J, Davidson BJ, Ringel MD, Burman KD. Papillary and follicular variant of papillary carcinoma of the thyroid: initial presentation and response to therapy. Otolaryngol Head Neck Surg 2005;132:840–844

    PubMed  Article  Google Scholar 

  17. Lang BH, Lo CY, Chan WF, Lam AK, Wan KY. Classical and follicular variant of papillary thyroid carcinoma: a comparative study on clinicopathologic features and long-term outcome. World J Surg 2006;30:752–758

    PubMed  Article  Google Scholar 

  18. Ozdemir D, Ersoy R, Cuhaci N, et al. Classical and follicular papillary carcinoma: comparison of clinical, ultrasonographical, cytological and histopathological features in 444 patients. Endocrinol Pathol 2011;22:58–65

    Article  Google Scholar 

  19. Cooper DS, Doherty GM, Haugen BR, et al. Management guidelines for patients with thyroid nodules and differenciated thyroid cancer. Thyroid 2006;16:1–33

    Article  CAS  Google Scholar 

  20. Albores-Saavedra J, Henson DE, Glazer E, Schwartz AM. Changing patterns in the incidence and survival of thyroid cancer with follicular phenotype—papillary, follicular, and anaplastic: a morphological and epidemiological study. Endocr Pathol 2007;18:1–7

    PubMed  Article  Google Scholar 

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Acknowledgments

We would like to thank to Dr. Zeynep Tarini, Dr. Sezen Koçarslan, Dr. Dilek Mil, and the Şanlıurfa Education and Research Hospital Pathology and General Surgery Department staffs and doctors for their help during the study.

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Affiliations

  1. Endocrinology and Metabolic Diseases Department, Turkish Ministry of Health, Şanlıurfa Education and Research Hospital, Esentepe, 63100, Şanlıurfa, Turkey

    Sibel Ertek

  2. Pathology Department, Turkish Ministry of Health, Şanlıurfa Education and Research Hospital, Şanlıurfa, Turkey

    Nuray Can Yılmaz, Özgül Vurupalmaz & Ahu Senem Demiröz

  3. Department of Internal Medicine, Aging and Kidney Diseases, Bologna University, Bologna, Italy

    Arrigo F. Cicero

  4. Endocrinology and Metabolic Diseases Department, Ufuk University Medical Faculty, Ankara, Turkey

    Gürbüz Erdoğan

Authors
  1. Sibel Ertek
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  2. Nuray Can Yılmaz
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  3. Arrigo F. Cicero
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  4. Özgül Vurupalmaz
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  5. Ahu Senem Demiröz
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  6. Gürbüz Erdoğan
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Correspondence to Sibel Ertek.

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Ertek, S., Yılmaz, N.C., Cicero, A.F. et al. Increasing Diagnosis of Thyroid Papillary Carcinoma Follicular Variant in South-East Anatolian Region: Comparison of Characteristics of Classical Papillary and Follicular Variant Thyroid Cancers. Endocr Pathol 23, 157–160 (2012). https://doi.org/10.1007/s12022-012-9216-9

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  • DOI: https://doi.org/10.1007/s12022-012-9216-9

Keywords

  • Thyroid
  • Papillary thyroid carcinoma
  • Follicular thyroid carcinoma
  • Thyroid nodules
  • Follicular variant thyroid carcinoma