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Primary Sellar Neuroblastoma Presenting with Syndrome of Inappropriate Secretion of Anti-diuretic Hormone

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Abstract

A 29-year-old Ethiopian man presented with marked bilateral visual loss, headache, hypopituitarism and significant hyponatraemia (115 mmol/L). A brain MRI scan demonstrated a large, lobulated, sellar and suprasellar mass, elevating the floor of the 3rd ventricle and compressing the optic chiasm. The patient underwent a transphenoidal resection of the mass followed by a craniotomy 10 days later. Histological examination demonstrated a Hyams’ grade III neuroblastoma with ectopic expression of vasopressin. He underwent fractionated radiotherapy at a dose of 60 Gy in 30 fractions. Fourteen months after the onset, he is well with no neuroimaging evidence of tumour recurrence. His serum and urine sodium are completely normalised.

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Acknowledgements

The authors are extremely grateful to Mr. Bob Chapman, Department of Histopathology, Chairing Cross Hospital, London, for his assistance in photography and Mrs. Poonam Singh for technical work.

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Authors and Affiliations

  1. Department of Medicine, Faculty of Medicine, Charing Cross Campus, Imperial College, London, UK

    Bishan Radotra, Ann Sandison, Emma C. I. Hatfield, Jill Moss, Karim Meeran & Federico Roncaroli

  2. Department of Surgery and Oncology, Faculty of Medicine, Charing Cross Campus, Imperial College, London, UK

    Vasileios Apostolopoulos, Nigel Mendoza & Mark Glaser

  3. Department of Radiology, Faculty of Medicine, Charing Cross Campus, Imperial College, London, UK

    Amrish Mehta

  4. Neuropathology Unit, Department of Medicine, Charing Cross Campus, Imperial College London, St. Dunstans Road, W6 8RP, London, UK

    Federico Roncaroli

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  1. Bishan Radotra
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  2. Vasileios Apostolopoulos
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  3. Ann Sandison
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  4. Emma C. I. Hatfield
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  10. Federico Roncaroli
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Correspondence to Federico Roncaroli.

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Radotra, B., Apostolopoulos, V., Sandison, A. et al. Primary Sellar Neuroblastoma Presenting with Syndrome of Inappropriate Secretion of Anti-diuretic Hormone. Endocr Pathol 21, 266–273 (2010). https://doi.org/10.1007/s12022-010-9140-9

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  • DOI: https://doi.org/10.1007/s12022-010-9140-9

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