Neuroinformatics

, Volume 11, Issue 3, pp 339–353 | Cite as

Semi-Supervised Multimodal Relevance Vector Regression Improves Cognitive Performance Estimation from Imaging and Biological Biomarkers

  • Bo Cheng
  • Daoqiang Zhang
  • Songcan Chen
  • Daniel I. Kaufer
  • Dinggang Shen
  • the Alzheimer’s Disease Neuroimaging Initiative
Original Article

Abstract

Accurate estimation of cognitive scores for patients can help track the progress of neurological diseases. In this paper, we present a novel semi-supervised multimodal relevance vector regression (SM-RVR) method for predicting clinical scores of neurological diseases from multimodal imaging and biological biomarker, to help evaluate pathological stage and predict progression of diseases, e.g., Alzheimer’s diseases (AD). Unlike most existing methods, we predict clinical scores from multimodal (imaging and biological) biomarkers, including MRI, FDG-PET, and CSF. Considering that the clinical scores of mild cognitive impairment (MCI) subjects are often less stable compared to those of AD and normal control (NC) subjects due to the heterogeneity of MCI, we use only the multimodal data of MCI subjects, but no corresponding clinical scores, to train a semi-supervised model for enhancing the estimation of clinical scores for AD and NC subjects. We also develop a new strategy for selecting the most informative MCI subjects. We evaluate the performance of our approach on 202 subjects with all three modalities of data (MRI, FDG-PET and CSF) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. The experimental results show that our SM-RVR method achieves a root-mean-square error (RMSE) of 1.91 and a correlation coefficient (CORR) of 0.80 for estimating the MMSE scores, and also a RMSE of 4.45 and a CORR of 0.78 for estimating the ADAS-Cog scores, demonstrating very promising performances in AD studies.

Keywords

Alzheimer’s disease (AD) Mild cognitive impairment (MCI) Semi-supervised learning Relevance vector regression (RVR) Multimodality 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Bo Cheng
    • 1
    • 2
  • Daoqiang Zhang
    • 1
    • 2
  • Songcan Chen
    • 1
  • Daniel I. Kaufer
    • 3
  • Dinggang Shen
    • 2
  • the Alzheimer’s Disease Neuroimaging Initiative
    • 2
  1. 1.Department of Computer Science and EngineeringNanjing University of Aeronautics and AstronauticsNanjingChina
  2. 2.Department of Radiology and BRICUniversity of North CarolinaChapel HillUSA
  3. 3.Department of NeurologyUniversity of North CarolinaChapel HillUSA

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