Abstract
Paragangliomas are neuroendocrine tumors that have the potential to secrete catecholamines. They have been linked to genetic mutations in the mitochondrial succinate dehydrogenase (SDH) complex. Patients can experience both physical symptoms and psychiatric symptoms like anxiety, depression, and psychosis. These symptoms can occur as paroxysmal episodes with periods of increased catecholamine secretion. We describe a patient with SDHB gene mutation, who has been diagnosed with a jugular paraganglioma, and was brought to the hospital under Baker Act for threats made online. Since diagnosis this patient has been experiencing both anxiety and post-traumatic stress disorder (PTSD). The patient and a family member report increased emotional lability, and the patient reports multiple daily episodes of anxiousness. This case outlines the connection between paragangliomas and psychiatric symptoms, the impact they can have on patients’ daily lives, and the importance of addressing the possibility of these symptoms and establishing a multispecialty healthcare team at the time of diagnosis.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by J.W., J.R., J.K., F.C. and E.K. The first draft of the manuscript was written by J.W., J.R., and J.K. and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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White, J.A., Rodriguez, J., Kandadai, J. et al. Increased anxiety and emotional lability in a patient with SDHB gene mutation paraganglioma: a call to multidisciplinary approach. Endocrine 83, 349–352 (2024). https://doi.org/10.1007/s12020-023-03555-9
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DOI: https://doi.org/10.1007/s12020-023-03555-9