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Can a novel drug dose be used for T3 suppression test?

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Abstract

Purpose

This study aimed to investigate whether 25 µg/day dose of triiodothyronine (T3) can also suppress thyroid stimulating hormone (TSH) level, as well as the routine dose of 50–100 µg/day in T3 suppression test, which is used to the distinguish between resistance to thyroid hormone (RTH) and TSH secreting pituitary adenoma.

Methods

In this prospective study, 26 patients with genetically proven RTH were randomly divided into two groups: Group 1 comprised 13 patients who were administered 50–100 µg/day T3 for 3–9 days, while Group 2 also comprised 13 patients who were administered 25 µg/day T3 for 7 days for T3 suppression test. The two groups’ responses to T3 suppression tests were compared.

Results

The comparison of the mean percentage changes in TSH values by the T3 suppression tests showed no significant differences between the groups, and a ≥80% decrease was detected in all patients. Nine patients in Group 1 and one patient in Group 2 reported that they had to use propranolol due to tachycardia developed during the test.

Conclusion

As higher doses of T3 can increase the risk of severe tachycardia during T3 suppression test, a low dose with 25 mcg/day for a week appears to be safer and more useful.

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Acknowledgements

Preparation for publication of this article is supported by the Society of Endocrinology and Metabolism of Turkey.

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Authors and Affiliations

  1. Department of Endocrinology, Diyarbakır Gazi Yaşargil Training and Research Hospital, 21010, Diyarbakır, Turkey

    Sedat Çetin, Mehmet Güven, Başak Bolayır, Mehmet Şimşek, Hikmet Soylu, Dilek Geneş & Halit Diri

  2. Department of General Surgery, Diyarbakır Gazi Yaşargil Training and Research Hospital, 21010, Diyarbakır, Turkey

    Nurettin Ay

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  1. Sedat Çetin
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  2. Mehmet Güven
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  3. Başak Bolayır
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  8. Halit Diri
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by S.Ç., M.G., B.B., M.Ş., H.S., D.G., N.A., and H.D. The first draft of the manuscript was written by S.Ç. and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Halit Diri.

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Conflict of interest

The authors declare no competing interests.

Ethical approval

This study was approved by the University of Health Sciences, Gazi Yaşargil Training and Research Hospital Ethics Committee with the Approval Date/No: 30.12.2022 / 297.

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Çetin, S., Güven, M., Bolayır, B. et al. Can a novel drug dose be used for T3 suppression test?. Endocrine 82, 586–589 (2023). https://doi.org/10.1007/s12020-023-03445-0

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  • DOI: https://doi.org/10.1007/s12020-023-03445-0

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