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Gastrinomas and non-functioning pancreatic endocrine tumors in multiple endocrine neoplasia syndrome type-1 (MEN-1)

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References

  1. S.S. Guo, M.P. Sawicki, Molecular and genetic mechanisms of tumorigenes in multiple endocrine neoplasia type-1. Mol. Endocrinol. 15, 1653–1664 (2001)

    Article  CAS  PubMed  Google Scholar 

  2. G. Effraimidis, U. Knigge, M. Rossing, P. Oturai, Å.K. Rasmussen, U. Feldt-Rasmussen, Multiple endocrine neoplasia type 1 (MEN-1) and neuroendocrine neoplasms (NENs). Semin. Cancer Biol. 79, 141–162 (2022)

    Article  CAS  PubMed  Google Scholar 

  3. R.V. Thakker, P.J. Newey, G.V. Walls et al. Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1). J. Clin. Endocrinol. Metab. 97, 2990–3011 (2012)

    Article  CAS  PubMed  Google Scholar 

  4. B. Niederle, A. Selberherr, D.K. Bartsch et al. Multiple endocrine neoplasia type 1 and the pancreas: diagnosis and treatment of functioning and non-functioning pancreatic and duodenal neuroendocrine neoplasia within the MEN1 syndrome – an international consensus statement. Neuroendocrinology 111, 609–630 (2021)

    Article  CAS  PubMed  Google Scholar 

  5. G.M. Doherty, Multiple endocrine neoplasia type 1: duodenopancreatic tumors. Surg. Oncol. 12, 135–143 (2003)

    Article  PubMed  Google Scholar 

  6. M.A. Kouvaraki, S.E. Shapiro, G.J. Cote et al. Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. World J. Surg. 30, 643–653 (2006)

    Article  PubMed  Google Scholar 

  7. M. Falconi, B. Eriksson, G. Kaltsas et al. ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors. Neuroendocrinology 103, 153–171 (2016)

    Article  CAS  PubMed  Google Scholar 

  8. L. Camera, S. Paoletta, C. Mollica et al. Screening of pancreaticoduodenal endocrine tumours in patients with MEN 1: multidetector-row computed tomography vs. endoscopic ultrasound. Radio. Med. 116, 595–606 (2011)

    Article  CAS  Google Scholar 

  9. C. Barbe, A. Murat, B. Dupas et al. Magnetic resonance imaging versus endoscopic ultrasonography for the detection of pancreatic tumors in multiple endocrine neoplasia type-1. Dig. Liv Dis. 44, 228–234 (2012)

    Article  Google Scholar 

  10. I.D. Nagtegaal, R.D. Odze, D. Klimstra et al. The 2019 WHO classification of tumours of the digestive system. Histopathology 76, 182–188 (2020)

    Article  PubMed  Google Scholar 

  11. C. Cappelli, U. Boggi, S. Mazzeo et al. Contrast enhancement pattern on multidetector CT predicts malignancy in pancreatic endocrine tumours. Eur. Radio. 25, 751–759 (2015)

    Article  Google Scholar 

  12. E. Belousova, G. Karmazanovsky, A. Kriger et al. Contrast-enhanced MDCT in patients with pancreatic neuroendocrine tumours: correlation with histological findings and diagnostic performance in differentiation between tumour grades. Clin. Radio. 72, 150–158 (2017)

    Article  CAS  Google Scholar 

  13. F. Salahshour, M.M. Mehrabinejad, A. Zare Dehnavi et al. Pancreatic neuroendocrine tumors (pNETs): the predictive value of MDCT characteristics in the differentiation of histopathological grades. Abdom. Radio. 45, 3155–3162 (2020)

    Article  Google Scholar 

  14. S. Chiloiro, F. Lanza, A. Bianchi, G. et al. Pancreatic neuroendocrine tumors in MEN-1 disease: a monocentric longitudinal and prognostic study. Endocrine 60, 362–367 (2018). https://doi.org/10.1007/S12020-017-1327-0

  15. V. Ramundo, M. Del Prete, V. Marotta et al. Impact of long-acting octreotide in patients with early-stage MEN1-related duodeno-pancreatic neuroendocrine tumours. Clin. Endocrinol. 80, 850–855 (2014)

    Article  CAS  Google Scholar 

  16. A. Faggiano, R. Modica, F. Lo Calzo et al. Lanreotide therapy vs active surveillance in MEN1-related pancreatic neuroendocrine tumors < 2 centimeters. J. Clin. Endocrinol. Metab. 105, dgz007 (2020). https://doi.org/10.1210/clinem/dgz007

  17. S. Lastoria, F. Marciello, A. Faggiano et al. Role of 68Ga-DOTATATE PET/CT in patients with multiple nedocrine neoplasia type 1 (MEN1). Endocrine 52, 488–494 (2016). https://doi.org/10.1007/s12020-015-0702y

  18. N. Lévy-Bohbot, C. Merle, P. Goudet et al. Prevalence, characteristics and prognosis of MEN 1-associated glucagonomas, VIPomas, and somatostatinomas: study from the GTE (Groupe des Tumeurs Endocrines) registry. Gastroenterol. Clin. Biol. 28, 1075–1081 (2004)

    Article  PubMed  Google Scholar 

  19. F. Tonelli, G. Fratini, G. Nesi et al. Pancreatectomy in multiple endocrine neoplasia type-1 related gastrinomas and pancreatic endocrine neoplasia. Ann. Surg. 244, 61–70 (2006)

    Article  PubMed  PubMed Central  Google Scholar 

  20. R. Casadei, C. Ricci, G. Taffurelli et al. Is total pancreatectomy as feasible, safe, efficacious and cost-effective as pancreaticoduodenectomy? A single center, prospective, observational study. J. Gastrointest. Surg. 20, 1595–1607 (2016). https://doi.org/10.1007/s11605-016-3201-4

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Authors

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Contributions

L.C.: conceptual design and manuscript draft. F.B.: data collection and literature search. R.M.: referring physician. L.M.: histopathological analysis. A.F.: manuscript revision. V.R.: MR study. V.G.: PPRT. A.C.: manuscript revision. S.M.: manuscript revision. A.B.: manuscript editing.

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Correspondence to Luigi Camera.

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The authors declare no competing interests.

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This is an observational study. The Local Ethical Committee declared that no ethical approval is required.

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Written informed consent was obtained by the patient for both.

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Camera, L., Boccadifuoco, F., Modica, R. et al. Gastrinomas and non-functioning pancreatic endocrine tumors in multiple endocrine neoplasia syndrome type-1 (MEN-1). Endocrine 81, 459–463 (2023). https://doi.org/10.1007/s12020-023-03373-z

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  • DOI: https://doi.org/10.1007/s12020-023-03373-z

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