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Clinical characteristics of hypercalcemic crises in a tertiary children’s hospital

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Abstract

Background

Hypercalcemic crisis is considered a critical and fatal endocrine condition. To date, few reports have focused on hypercalcemic crises in children.

Aim

To explore the etiology and identify the clinical characteristics related to hypercalcemic crises in children.

Methods

We enrolled 101 children diagnosed with hypercalcemia between January 1, 2016 and December 31, 2021, admitted to the Children’s Hospital of Chongqing Medical University. Electronic medical records were reviewed to determine the causes and clinical characteristics of hypercalcemic crises.

Results

Hypercalcemic crises occurred in 28 admissions during the 6-year period; 64% of the patients enrolled in the study were infants. The mean corrected total serum calcium was 4.6 ± 0.2 mmol/l. Tumor and hereditary diseases were found in 12 (43%) and 7 (25%) patients, respectively. The ratio of iatrogenic factors was 11% (3/28), and all 3 patients received a blood transfusion. The incidence of poor prognosis in the tumor cases was 50%. Timely intervention including hemodialysis, pamidronate, and etiological treatment was effective in decreasing calcium levels.

Conclusion

Hypercalcemic crisis is a serious electrolyte disturbance that has the potential for high mortality. The main causes are tumors and hereditary diseases in children. The lack of unique characteristics makes it difficult to recognize by medical caregivers. Early diagnosis and timely intervention could improve the prognosis.

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Authors and Affiliations

  1. Department of Medical General Ward, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China

    Xuhua Xia, Jie Cao, Chunli Long, Xin Chen & Jiajia Zheng

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Xia, X., Cao, J., Long, C. et al. Clinical characteristics of hypercalcemic crises in a tertiary children’s hospital. Endocrine 81, 175–181 (2023). https://doi.org/10.1007/s12020-023-03347-1

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