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Pesticides as endocrine disruptors: programming for obesity and diabetes

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Abstract

Purpose

Exposure to pesticides has been associated with obesity and diabetes in humans and experimental models mainly due to endocrine disruptor effects. First contact with environmental pesticides occurs during critical phases of life, such as gestation and lactation, which can lead to damage in central and peripheral tissues and subsequently programming disorders early and later in life.

Methods

We reviewed epidemiological and experimental studies that associated pesticide exposure during gestation and lactation with programming obesity and diabetes in progeny.

Results

Maternal exposure to organochlorine, organophosphate and neonicotinoids, which represent important pesticide groups, is related to reproductive and behavioral dysfunctions in offspring; however, few studies have focused on glucose metabolism and obesity as outcomes.

Conclusion

We provide an update regarding the use and metabolic impact of early pesticide exposure. Considering their bioaccumulation in soil, water, and food and through the food chain, pesticides should be considered a great risk factor for several diseases. Thus, it is urgent to reformulate regulatory actions to reduce the impact of pesticides on the health of future generations.

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R.A.M., B.S.S., E.G.M., and P.C.L. designed, wrote, and approve the final version of this mini-review.

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This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico- CNPq, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior- CAPES, and Fundação Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro- FAPERJ.

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  1. Laboratory of Endocrine Physiology, Biology Institute, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil

    Rosiane Aparecida Miranda, Beatriz Souza Silva, Egberto Gaspar de Moura & Patrícia Cristina Lisboa

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Miranda, R.A., Silva, B.S., de Moura, E.G. et al. Pesticides as endocrine disruptors: programming for obesity and diabetes. Endocrine 79, 437–447 (2023). https://doi.org/10.1007/s12020-022-03229-y

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