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Cortex or cancellous—which is early for the decrease of bone content for vertebral body in health?

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Abstract

Objective

To obtain the cortex and cancellous parameter of the vertebral bone of healthy subjects using QCT. To explore which is earlier or faster for bone loss with age.

Materials and methods

733 physical examiners underwent chest low-dose CT examination were recruited, from April 1, 2021 to October 1, 2021. QCT sequence was used to obtain the bone mineral density of T12-L2 vertebral body without additional radiation. The mass and area of vertebral cortex and cancellous at the central level of L2 vertebral body were measured. The age -related characteristics of vertebral cortex and cancellous between male and female was analyzed and compared.

Results

The vBMD of T12-L2 vertebral body decreased with age. Significant differences were found in volumetric bone mineral density (vBMD) of T12-L2 vertebral body. For female, significant differences were found in bone content involving cortical mass, cancellous mass, cortical area, cancellous area, cortical mass/cancellous mass and cortical area/cancellous area in different age groups, respectively. The cortical mass decreased with age in female. The cancellous mass of female increased and then decreased with peak at 31–40 y. The cortical area of female decreased gradually before 71 y. The cancellous area of female increased and then decreased with peak at 51–60 y. The values of mass ratio and area ratio in female showed a slowly downward trend with age. Significant differences of bone content between non-menopausal and menopausal women were found except the cancellous mass. For male, no significant differences were found in all parameters of bone content.

Conclusion

The changes of vertebral BMD, bone content of cortex and cancellous have different characteristics in different age. The change of cortex in female maybe earlier and faster than that of cancellous, especially in menopausal women.

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Author notes

  1. These authors contributed equally: Jujia Li, Lin Bai

Authors and Affiliations

  1. Department of Radiology, Hebei Province Biomechanical Key Laboratory of Orthopedics, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, Hebei, China

    Lin Bai, Jujia Li, Congcong Ren, Ming Wang, Fan Yang, Qian Li, Jian Zhao & Ping Zhang

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  1. Lin Bai
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Correspondence to Jian Zhao or Ping Zhang.

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This study was approved by the Ethics Committee of the Third Hospital of Hebei Medical University, and all participants gave informed consent before taking part.

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Bai, L., Li, J., Ren, C. et al. Cortex or cancellous—which is early for the decrease of bone content for vertebral body in health?. Endocrine 78, 597–604 (2022). https://doi.org/10.1007/s12020-022-03194-6

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  • DOI: https://doi.org/10.1007/s12020-022-03194-6

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