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The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus

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Abstract

Purpose

To investigate the relationship between estimated glucose disposal rate (eGDR) and bone turnover markers in patients with type 2 diabetes mellitus (T2DM).

Materials and methods

This is a cross-sectional study, which recruited 549 patients with T2DM. The eGDRs of patients were calculated based on the presence of hypertension, glycated hemoglobin, and body mass index. All patients were divided into high-eGDR group and low-eGDR group using the median of eGDR as the boundary. The patients were further divided into two subgroups: males and postmenopausal females.

Results

The lower the eGDR, the more severe was insulin resistance. The levels of osteocalcin (OC), type I collagen carboxyl-terminal peptide (β-CTX), and type I procollagen amino-terminal peptide (PINP) were significantly lower in the low-eGDR group than those in the high-eGDR group. The eGDR was positively correlated with OC, β-CTX, and PINP in all patients, and in the male subgroups. In the postmenopausal female subgroup, there was no correlation between eGDR and OC, β-CTX, or PINP. In addition, this positive correlation remained after adjusting for other factors in multilinear regression analysis.

Conclusion

Our study was the first to demonstrate that eGDR is positively correlated with bone turnover markers in patients with T2DM. This correlation was observed among the male patients with T2DM but not among postmenopausal female patients with T2DM.

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Authors and Affiliations

  1. Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, China

    Zelin Li, Cuijuan Qi, Xiaoyu Pan, Yujiao Jia, Xuetong Zhao, Chenqian Deng & Shuchun Chen

  2. Graduate School of Hebei Medical University, Shijiazhuang, Hebei, China

    Zelin Li, Yujiao Jia & Shuchun Chen

  3. Hebei North University, Zhangjiakou, Hebei, China

    Xuetong Zhao, Chenqian Deng & Shuchun Chen

  4. Hebei Key Laboratory of Metabolic Diseases, Shijiazhuang, Hebei, China

    Shuchun Chen

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  1. Zelin Li
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Z.L., X.P., Y.J., X.Z., and C.D. The first draft of the manuscript was written by Z.L. Writing (review and editing) was performed by S.C. and C.Q.; all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Shuchun Chen.

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The authors declare no competing interests.

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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Hebei General Hospital (Date May 8, 2020/No. 202027).

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Informed consent was obtained from all individual participants included in the study.

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Li, Z., Qi, C., Pan, X. et al. The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus. Endocrine 77, 242–251 (2022). https://doi.org/10.1007/s12020-022-03090-z

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