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Insulin resistance and cardiometabolic indexes: comparison of concordance in working-age subjects with overweight and obesity

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Abstract

Purpose

The aim of the study was to evaluate indexes of insulin resistance and cardiometabolic risk in a large population of workers with overweight or obesity, in order to identify a possible efficient, cheap and simple strategy to apply in workers’ health surveillance.

Methods

The evaluation of IR and cardiometabolic risk indexes (HOMA, QUICKI, Ty/HDLC, TyG, insuTAG, Castelli risk indexes 1 and 2, non-HDLC, TRL-C, AIP, and VAI) was performed in a population of 1195 working-age subjects with overweight or obesity (322 males, mean age 49 ± 11 years).

Results

The prevalence of IR and cardiometabolic risk was higher among males for all indexes. Aging, waist circumference, BMI, blood pressure, glucose, CRP, fibrinogen and uric acid were correlated more frequently with IR/cardiometabolic indexes in women, homocysteine in men. The percentage of the workers identified as insulin resistant (IR+) or at higher cardiometabolic risk greatly vary according to the different index used.

Conclusion

With a small group of biomarkers and anthropometric measures (fasting glucose and insulin, lipid profile, BMI and waist circumference) is possible to calculate a number of IR/cardiometabolic indexes, which, likely reflecting different pathophysiological aspects also related to gender, might help in a personalized evaluation of IR and cardiometabolic risk.

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Acknowledgements

Center of Obesity and Work, Occupational Health Unit of Clinica del Lavoro “L. Devoto”, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan (Italy).

Author contributions

C.V., L.V., S.A.T.: study conceptualization; S.D.P., L.T., S.A.T., F.B., S.T., L.V., M.G.: data acquisition, and database assessment; C.V., M.G.: data analysis; C.V., L.V.: drafting of the manuscript. All authors contributed to the manuscript intellectual content and gave approval to the final version.

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Authors and Affiliations

  1. Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico. Occupational Health Unit, Obesity and Work Center, EASO Collaborating Center for Obesity Management, Milan, Italy

    Luisella Vigna & Salvina Di Piazza

  2. Fondazione IRCCS Cà Grande Ospedale Maggiore Policlinico. Clinical Chemistry and Microbiology Bacteriology and Virology Units, Milan, Italy

    Amedea Silvia Tirelli

  3. Cardiometabolic Risk Unit, Institute of Clinical Physiology, CNR, Pisa, Italy

    Melania Gaggini

  4. Emergency Medicine Residency Program, Marche Polytechnic University, Ancona, Italy

    Laura Tomaino

  5. Fondazione IRCCS Cà Grande Ospedale Maggiore Policlinico. UOC Pediatric Nephrology, Dialysis and Transplantation, Milan, Italy

    Stefano Turolo

  6. Clinica Medica, Azienda Ospedali Riuniti, Department of Internal Medicine, Azienda ospedaliera Universitaria Ospedali Riuniti, Ancona, Italy

    Gianluca Moroncini

  7. Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy

    Kyriazoula Chatzianagnostou & Cristina Vassalle

  8. Former Associate Professor of Clinical Biochemistry, Board Certify in Clinical Chemistry and Biochemistry, Università degli Studi di Milano, Milan, Italy

    Fabrizia Bamonti

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  1. Luisella Vigna
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Correspondence to Cristina Vassalle.

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The study was conducted according to the Good Clinical Practice guidelines and approved by Human Ethic Committee of Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (Registration number: 852).

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Vigna, L., Tirelli, A.S., Gaggini, M. et al. Insulin resistance and cardiometabolic indexes: comparison of concordance in working-age subjects with overweight and obesity. Endocrine 77, 231–241 (2022). https://doi.org/10.1007/s12020-022-03087-8

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