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Health-related quality of life in men with osteoporosis: a systematic review and meta-analysis

Endocrine volume 74, pages 270–280 (2021)Cite this article

Abstract

Purpose

The increased social and economic burdens make osteoporosis in men an emerging public health issue. However, the quality of life among men with osteoporosis is still unclear. This systematic review and meta-analysis aimed to evaluate the health-related quality of life (HRQoL) among men with osteoporosis or osteoporotic fracture.

Methods

PubMed, EMBASE, and the Cochrane Library database were systematically searched from inception to May 2021. Studies were included if they used validated questionnaires to measure HRQoL among osteoporotic men. A meta-analysis was performed using a random-effects model or fixed-effects model to calculate the standard mean difference (SMD) or mean difference (MD) with 95% confidential interval (95% CI).

Results

14 studies involving 6338 male participants were chosen for systematic review, of which 10 were included in the meta-analysis. Men with osteoporosis had poorer global HRQoL and multiple dimensions of HRQoL than men without osteoporosis. Hip fracture, vertebral fractures, or wrist fractures dramatically impaired HRQoL of men, and physical function was declined even before hip fracture (SMD = −0.60, 95% CI, −0.82 to −0.39). Femoral and lumbar BMD was positively correlated with HRQoL, and a number of fragility fractures and time since fracture had negative effects on HRQoL. Effective anti-osteoporotic drugs could improve HRQoL of men.

Conclusion

The health-related life quality of men was significantly impaired by osteoporosis and fracture of the hip, vertebral, or wrist. We should pay more attention to the diagnosis and treatment of male osteoporosis to improve the life quality of men.

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Data availability

All data generated or analyzed during this study are included in this published article.

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Funding

This work is supported by National Key R&D Program of China (2018YFA0800801), National Natural Science Foundation of China (Nos. 81873668, 82070908), and Beijing Natural Science Foundation (7202153).

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Authors and Affiliations

  1. Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan No. 1, Dongcheng District, Beijing, China

    Jing Hu, Wenbing Zheng, Dichen Zhao, Lei Sun, Bingna Zhou, Jiayi Liu, Ou Wang, Yan Jiang, Weibo Xia, Xiaoping Xing & Mei Li

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  1. Jing Hu
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Correspondence to Mei Li.

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Hu, J., Zheng, W., Zhao, D. et al. Health-related quality of life in men with osteoporosis: a systematic review and meta-analysis. Endocrine 74, 270–280 (2021). https://doi.org/10.1007/s12020-021-02792-0

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Key words

  • Osteoporosis in men
  • HRQoL
  • Bone fracture
  • Anti-osteoporotic treatment