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Ιrisin levels in postmenopausal women with an incident hip fracture

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References

  1. Huh, J.Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M.T., Schneider, B.E., Mantzoros, C.S. (2012). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism: clinical and experimental 61(12), 1725–1738. https://doi.org/10.1016/j.metabol.2012.09.002

  2. Colaianni, G., Cinti, S., Colucci, S., Grano, M. (2017). Irisin and musculoskeletal health. Annals of the New York Academy of Sciences 1402(1), 5–9. https://doi.org/10.1111/nyas.13345

  3. Anastasilakis, A.D., Polyzos, S.A., Makras, P., Douni, E., Mantzoros, C.S. (2019). Irisin: good or bad for the bone? A new path forward after the reported discovery of irisin receptor? Metabolism: clinical and experimental 93, 100–102. https://doi.org/10.1016/j.metabol.2019.01.013

  4. Colaianni, G., Faienza, M.F., Sanesi, L., Brunetti, G., Pignataro, P., Lippo, L. et al. (2019). Irisin serum levels are positively correlated with bone mineral status in a population of healthy children. Pediatric Research 85(4), 484–488. https://doi.org/10.1038/s41390-019-0278-y

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  6. Colaianni, G., Errede, M., Sanesi, L., Notarnicola, A., Celi, M., Zerlotin, R. et al. (2021). Irisin correlates positively with BMD in a cohort of older adult patients and downregulates the senescent marker p21 in osteoblasts. Journal of Bone and Mineral Research 36(2), 305–314. https://doi.org/10.1002/jbmr.4192

  7. Anastasilakis, A.D., Polyzos, S.A., Makras, P., Gkiomisi, A., Bisbinas, I., Katsarou, A. et al. (2014). Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months. Osteoporosis International 25(5), 1633–1642. https://doi.org/10.1007/s00198-014-2673-x

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  9. Yan, J., Liu, H.J., Guo, W.C., Yang, J. (2018). Low serum concentrations of Irisin are associated with increased risk of hip fracture in Chinese older women. Joint Bone Spine 85(3), 353–358. https://doi.org/10.1016/j.jbspin.2017.03.011

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Author contributions

Conception and design of the work: A.D.A., S.A.P. and M.S. Acquisition, analysis, or interpretation of data: A.D.A., S.A.P., K.D., P.M., M.P.Y., A.P., S.G., C.N., I.B. and M.S. Drafting the work: A.D.A. Revising the work critically for important intellectual content: S.A.P., P.M., M.P.Y., A.P. and M.S. Final approval of the submitted version: A.D.A., S.A.P., K.D., P.M., M.P.Y., A.P., S.G., C.N., I.B. and M.S. Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved: A.D.A., S.A.P., K.D., P.M., M.P.Y., A.P., S.G., C.N., I.B. and M.S.

Funding

This work was not supported by any grant, fund, or institution.

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Authors and Affiliations

  1. Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece

    Athanasios D. Anastasilakis

  2. First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Stergios A. Polyzos & Charikleia Ntenti

  3. 2nd Orthopedic Department, 424 General Military Hospital, Thessaloniki, Greece

    Dimitrios Kitridis & Matthaios Savvidis

  4. Department of Endocrinology and Diabetes and Department of Medical Research, 251 Hellenic Air Force & VA General Hospital, Athens, Greece

    Polyzois Makras

  5. Endocrinology Unit, 1st Department of Propaedeutic and Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

    Maria P. Yavropoulou

  6. Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy

    Andrea Palermo

  7. “Analysis” laboratories, Thessaloniki, Greece

    Spyridon Gerou & Iris Ballaouri

Authors
  1. Athanasios D. Anastasilakis
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  2. Stergios A. Polyzos
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  3. Dimitrios Kitridis
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  4. Polyzois Makras
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  5. Maria P. Yavropoulou
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  6. Andrea Palermo
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  7. Spyridon Gerou
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  8. Charikleia Ntenti
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  9. Iris Ballaouri
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  10. Matthaios Savvidis
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Corresponding author

Correspondence to Athanasios D. Anastasilakis.

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All procedures performed in the study were in accordance with the ethical standards of the institutional research committees and with the 1964 Helsinki declaration and its later amendments.

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Anastasilakis, A.D., Polyzos, S.A., Kitridis, D. et al. Ιrisin levels in postmenopausal women with an incident hip fracture. Endocrine 73, 719–722 (2021). https://doi.org/10.1007/s12020-021-02738-6

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  • DOI: https://doi.org/10.1007/s12020-021-02738-6

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