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Insulin-degrading enzyme higher in subjects with metabolic syndrome

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Abstract

Metabolic syndrome (MS) is comprised of a cluster of abnormalities in glucose, lipid, and vascular homeostasis, which is most commonly linked to abdominal obesity. MS heralds increased risk for development of diabetes and is linked to impairment in insulin signaling. Insulin-degrading enzyme (IDE) is one of the mechanisms through which insulin blood levels are maintained. It has been previously suggested that controlling IDE levels could provide yet another potential therapeutic approach in diabetes. Here we aim to investigate whether changes in serum IDE levels correlate with the severity of MS. Using a highly sensitive ELISA assay of active IDE in human serum, we found a strong correlation between circulating IDE levels and circulating levels of triglycerides, insulin, and c-peptide and an inverse correlation with HDL cholesterol (HDLc). Serum IDE levels were higher in MS subjects than in control subjects. Hence, circulating IDE may serve as a tool to identify subjects with abnormal insulin metabolism, possibly those with MS that are at risk to develop diabetes.

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Funding

The research was supported by Sagol school of neuroscience and the Shoham foundation (to D.F. and Y.S.).

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Author notes

  1. These authors contributed equally: Y. Sofer, Y. Nash

Authors and Affiliations

  1. Institute of Endocrinology, Metabolism and Hypertension and The Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv, Israel

    Y. Sofer, E. Osher, S. Shaklai, K. M. Tordjman, M. Serebro, E. B. Touati, M. Yacobi Bach, Y. Marcus, B. Tal, J. Sack, G. Shefer, M. Margaliot, N. Landis & N. Stern

  2. Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    Y. Nash, O. Fursht, G. Goldsmith & D. Frenkel

  3. Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

    Y. Nash & D. Frenkel

  4. Department of Molecular Microbiology and Biotechnology, The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv, Israel

    L. Nahary & I. Benhar

  5. Laboratory Medicine, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    I. Goldiner

  6. Hebrew University-Hadassah Braun School of Public Health and Community Medicine, Jerusalem, Israel

    W. Abu Ahmad

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  1. Y. Sofer
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Sofer, Y., Nash, Y., Osher, E. et al. Insulin-degrading enzyme higher in subjects with metabolic syndrome. Endocrine 71, 357–364 (2021). https://doi.org/10.1007/s12020-020-02548-2

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