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Characteristics of nephropathy in severely obese Japanese patients complicated with type 2 diabetes mellitus: a cross-sectional cohort study

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Abstract

Purpose

We aimed to investigate the characteristics of kidney disease in severely obese Japanese patients with type 2 diabetes mellitus (T2DM).

Methods

This was a cross-sectional study of severely obese patients (body mass index ≥35 kg/m2) with T2DM treated at Jinnouchi Hospital, Kumamoto, Japan.

Results

A total of 3128 T2DM patients visited the hospital during the survey period, of whom 55 patients (1.7%) were severely obese and 50 patients were enrolled. In terms of diabetic nephropathy (DN), twenty-five patients were stage 1 (non-DN, 50.0%), sixteen were stage 2 (32.0%), five were stage 3 (10.0%), and four were stage 4 (8.0%). There were significant differences in the presence of urinary occult blood (P = 0.01) and history of cardiovascular disease (CVD) (P = 0.04) between patients with DN (stages 2–4) and those without DN (stage 1). The presence of urinary occult blood (odds ratio [OR], 4.96; 95% confidence interval, 1.32–18.6; P = 0.02) was significantly associated with the presence of DN according to multivariate logistic regression analysis with forced inclusion of age, sex, and CVD history.

Conclusions

Urinary occult blood may be a significant independent factor associated with the presence of nephropathy in severely obese Japanese patients with T2DM. The presence of urinary occult blood could thus be an important pathogenic factor in obesity-related nephropathy in patients with T2DM.

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Acknowledgements

We thank Susan Furness, PhD, from Edanz Group (https://en-author-services.edanzgroup.com/) for editing a draft of this manuscript.

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Authors and Affiliations

  1. Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan

    Noboru Kurinami, Seigo Sugiyama, Hiroko Ijima, Akira Yoshida, Kunio Hieshima, Fumio Miyamoto, Keizo Kajiwara, Katsunori Jinnouchi, Tomio Jinnouchi & Hideaki Jinnouchi

  2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan

    Noboru Kurinami & Masatoshi Nomura

  3. Division of Cardiovascular Medicine, Diabetes Care Center, Jinnouchi Hospital, Kumamoto, Japan

    Seigo Sugiyama

  4. Division of Preventive Cardiology, Department of Cardiovascular Medicine, Kumamoto University Hospital, Kumamoto, Japan

    Hideaki Jinnouchi

Authors
  1. Noboru Kurinami
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  2. Seigo Sugiyama
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  3. Hiroko Ijima
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  4. Akira Yoshida
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  5. Kunio Hieshima
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  7. Keizo Kajiwara
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  8. Katsunori Jinnouchi
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  9. Tomio Jinnouchi
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  10. Masatoshi Nomura
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  11. Hideaki Jinnouchi
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Corresponding author

Correspondence to Masatoshi Nomura.

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Conflict of interest

HJ has received honoraria from Novo Nordisk, Sanofi, AstraZeneca Pharmaceuticals, Astellas Pharma, Boehringer Ingelheim, Daiichi-Sankyo, Eli Lilly, Takeda, and Novartis Pharmaceuticals. SS has received honoraria from MSD, AstraZeneca Pharmaceuticals, Ono Pharmaceutical, Bayer Yakuhin, Ltd., and Novo Nordisk. There are no other potential conflicts of interest relevant to this article.

Ethics approval

The article does not contain any studies with animals performed by any of the authors. The study was conducted in accordance with the Declaration of Helsinki and the study protocol was approved by the Human Ethics Review Committee of Jinnouchi Hospital.

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Informed consent was obtained from all individual participants included in the study.

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Kurinami, N., Sugiyama, S., Ijima, H. et al. Characteristics of nephropathy in severely obese Japanese patients complicated with type 2 diabetes mellitus: a cross-sectional cohort study. Endocrine 70, 509–516 (2020). https://doi.org/10.1007/s12020-020-02462-7

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  • DOI: https://doi.org/10.1007/s12020-020-02462-7

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