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Baseline levels determine magnitude of increment in 25 hydroxy vitamin D following vitamin D3 prescription in healthy subjects

Endocrine volume 64, pages 378–383 (2019)Cite this article

Abstract

Introduction

Vitamin D deficiency is a major health problem which affects about one billion people in the world. Although, vitamin D supplementation is recommended as standard treatment of vitamin D deficiency, there are controversies on dose response relationship. In this regard, the present study aimed to determine the impact of vitamin D3 supplement on raising of serum 25 hydroxyvitamin D[25(OH)D] in healthy subjects with varying degrees of vitamin D deficiency.

Materials and methods

In this clinical trial 114 subjects with varying degrees of vitamin D deficiency were entered and divided into three groups: serum levels of 25(OH) D less than 10 ng/ml, 10–20 ng/ml, and 20–30 ng/ml. All of the participants were given 50,000 units vitamin D3 per week for 8 weeks, thereafter, changes in serum levels of vitamin D and PTH were evaluated at week twelve. The results were analyzed using SPSS version 16 and P < 0.05 was considered to be significant.

Results

Of the 114 vitamin D deficient subjects, serum level of vitamin D was below 10 ng/ml in 22 persons (19.3%), 10–20 ng/ml in 52 persons (45.6%) and 20–30 ng/ml in 40 persons (35.1%). Following vitamin D prescription all people with varying degrees of vitamin D deficiency obtained a favorable serum level. The increase in vitamin D levels were 26.4, 18.5, and 8.3 ng/ml, in individuals with baseline vitamin D levels below 10 ng/ml, 10–20 ng/ml and 20–30 ng/ml, respectively. The changes in 25(OH) vitamin D in all three groups were significant (P < 0.05), nonetheless no significant alterations in serum levels of PTH were observed (P > 0.05).

Conclusion

Our results indicated an inverse relationship between baseline serum levels of 25(OH) D and its increment following treatment with vitamin D3. Therefore, the magnitude of increments in serum 25(OH) D is greater in subjects with lower baseline levels of 25(OH) D.

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Author information

Affiliations

  1. Department of Internal Medicine, Ali-EbneAbitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran

    Mahmoud Ali Kaykhaei, Mahdieh Khodadoost, Zahra Haidari, Azra karimkoshteh & Mahnaz Sandoughi

  2. Genetics of non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

    Mahmoud Ali Kaykhaei

  3. Department of Food Sciences and Nutrition, Zahedan University of Medical Sciences, Zahedan, Iran

    Ali Reza Dashipour

  4. Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

    Mahnaz Sandoughi

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  1. Mahmoud Ali Kaykhaei
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Kaykhaei, M.A., Khodadoost, M., Dashipour, A.R. et al. Baseline levels determine magnitude of increment in 25 hydroxy vitamin D following vitamin D3 prescription in healthy subjects. Endocrine 64, 378–383 (2019). https://doi.org/10.1007/s12020-019-01881-5

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Keywords

  • Vitamin D deficiency
  • Dose response relationship
  • Treatment