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Thyroid Cancer Epidemiology in South Spain: a population-based time trend study

Endocrine volume 62, pages 423–431 (2018)Cite this article

Abstract

Purpose

Thyroid cancer (TC) is the most common malignant disease of the endocrine system. The aim of this study was to analyze incidence and mortality trends of TC (C73 according to ICD-O-3) in Granada (Southern Spain) during the period 1985–2013, by sex, age, and histological type.

Methods

This is a population-based cross-sectional study. Incidence data were obtained from the population-based Cancer Registry of Granada. All newly diagnosed cases of thyroid cancer over the period 1985–2013 were included. Joinpoint regression analysis with age-standardized rates were used to estimate annual percentage change (APC), CI 95% and turning points in trends. Results are presented by sex, age group, and histological type.

Results

During the study period there were 1265 diagnosed cases of TC in Granada (72.6% in women). Incidence trends significantly increased in both men (APC: + 5.4%) and women (APC: + 4.7%). The most common histological types in both sexes were papillary (74.8%) and follicular (16.8%). The incidence has increased during the study period mainly due to papillary carcinoma, which has increased annually around 6% in both sexes. TC mortality trend during this period decreased in men (APC: −0.3%) and women (APC: −2.3%).

Conclusion

Our data showed an increasing trend in incidence of thyroid cancer in Granada, especially in women between 55–64 years. Mortality showed a slight decrease trend during the study period in both sexes. Papillary carcinoma was the most common histological type, with an increase of the relative weight of papillary microcarcinomas. Our study is in accordance with the European and worldwide trends in thyroid cancer incidence and mortality and sex differences.

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References

  1. F. Bray, J.S. Ren, E. Masuyer, J. Ferlay, Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int. J. Cancer 132, 1133–1145 (2013). https://doi.org/10.1002/ijc.27711

    CAS  Article  PubMed  Google Scholar 

  2. B.A. Kilfoy, T. Zheng, T.R. Holford, X. Han, M.H. Ward, A. Sjodin, Y. Zhang, Y. Bai, C. Zhu, G.L. Guo, N. Rothman, Y. Zhang, International patterns and trends in thyroid cancer incidence, 1973-2002. Cancer Causes Control 20, 525–531 (2009). https://doi.org/10.1007/s10552-008-9260-4

    Article  PubMed  Google Scholar 

  3. G. Pellegriti, F. Frasca, C. Regalbuto, S. Squatrito, R. Vigneri, Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J. Cancer Epidemiol. 2013, 965212 (2013). https://doi.org/10.1155/2013/965212

    Article  PubMed  PubMed Central  Google Scholar 

  4. F. Bray, M. Colombet, L. Mery, M. Piñeros, A. Znaor, Z.R., F.J. Cancer Incidence in Five Continents, Vol. XI (electronic version). (International Agency for Research on Cancer, Lyon), 2017)

    Google Scholar 

  5. J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D.M. Parkin, D. Forman, F. Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer 136, E359–E386 (2015). https://doi.org/10.1002/ijc.29210

    CAS  Article  PubMed  Google Scholar 

  6. J. Ferlay, E. Steliarova-Foucher, J. Lortet-Tieulent, S. Rosso, J.W.W. Coebergh, H. Comber, D. Forman, F. Bray, Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur. J. Cancer 49, 1374–1403 (2013). https://doi.org/10.1016/j.ejca.2012.12.027

    CAS  Article  PubMed  Google Scholar 

  7. W. H. O.: Globocan 2012 - Home, http://globocan.iarc.fr/Default.aspx

  8. J. Galceran, A. Ameijide, M. Carulla, A. Mateos, J.R. Quirós, D. Rojas, A. Alemán, A. Torrella, M. Chico, M. Vicente, J.M. Díaz, N. Larrañaga, R. Marcos-Gragera, M.J. Sánchez, J. Perucha, P. Franch, C. Navarro, E. Ardanaz, J. Bigorra, P. Rodrigo, R.P. Bonet, A. Mateos, E. Almar, J.R. Quirós, M.V. Argüelles, D. Rojas, A. Alemán, A. Torrella, C. Sabater, P. Botella, M. Chico, M. Ripoll, C. Díaz, M. Vicente, N. Fuster, J.M. Díaz, R. Jiménez, A.I.M. Navarro, N. Larrañaga, J. Bidaurrazaga, A. Lopez-de-Munain, R. Marcos-Gragera, À. Izquierdo, L. Vilardell, M.J. Sánchez, E. Molina-Portillo, M. Rodríguez-Barranco, J. Perucha, P. Franch, M. Ramos, C. Navarro, M.D. Chirlaque, D. Salmerón, E. Ardanaz, M. Guevara, R. Burgui, J. Galceran, A. Ameijide, M. Carulla, J. Bigorra, R.P. Bonet, E. Pardo, Cancer incidence in Spain, 2015. Clin. Transl. Oncol. 19, 799–825 (2017). https://doi.org/10.1007/s12094-016-1607-9

    CAS  Article  PubMed  Google Scholar 

  9. ECIS European Commission, https://ecis.jrc.ec.europa.eu/

  10. M.D. Chirlaque, D. Salmerón, J. Galceran, A. Ameijide, A. Mateos, A. Torrella, R. Jiménez, N. Larrañaga, R. Marcos-Gragera, E. Ardanaz, M. Sant, P. Minicozzi, C. Navarro, M.J. Sánchez, REDECAN Working Group: Cancer survival in adult patients in Spain. Results from nine population-based cancer registries. Clin. Transl. Oncol. 20, 201–211 (2017). https://doi.org/10.1007/s12094-017-1710-6

    Article  Google Scholar 

  11. WHO cancer mortality database (IARC), http://www-dep.iarc.fr/WHOdb/WHOdb.htm, Accessed on 22/07/2018 (2015)

  12. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, D. Forman, Global cancer statistics. CA Cancer J. Clin. 61, 69–90 (2011). https://doi.org/10.3322/caac.20107

    Article  PubMed  Google Scholar 

  13. C. La Vecchia, M. Malvezzi, C. Bosetti, W. Garavello, P. Bertuccio, F. Levi, E. Negri, Thyroid cancer mortality and incidence: a global overview. Int. J. Cancer 136, 2187–2195 (2015). https://doi.org/10.1002/ijc.29251

    CAS  Article  PubMed  Google Scholar 

  14. L. Dal Maso, M. Lise, P. Zambon, F. Falcini, E. Crocetti, D. Serraino, C. Cirilli, R. Zanetti, M. Vercelli, S. Ferretti, F. Stracci, V. de Lisi, S. Busco, G. Tagliabue, M. Budroni, R. Tumino, A. Giacomin, S. Franceschi, A.W. Group, Incidence of thyroid cancer in Italy, 1991-2005: time trends and age-period-cohort effects. Ann. Oncol. 22, 957–963 (2011). https://doi.org/10.1093/annonc/mdq467

    CAS  Article  PubMed  Google Scholar 

  15. M.D. Chirlaque, F. Moldenhauer, D. Salmerón, C. Navarro, Patrón evolutivo de la incidencia de cáncer de tiroides en la Región de Murcia de 1984 a 2008. Gac. Sanit. 28, 397–400 (2014). https://doi.org/10.1016/J.GACETA.2014.05.005

    Article  PubMed  Google Scholar 

  16. L. Raposo, S. Morais, M.J. Oliveira, A.P. Marques, M. José Bento, N. Lunet, Trends in thyroid cancer incidence and mortality in Portugal. Eur. J. Cancer Prev. 2008, 1 (2016). https://doi.org/10.1097/CEJ.0000000000000229

    Article  Google Scholar 

  17. C. Bosetti, P. Bertuccio, M. Malvezzi, F. Levi, L. Chatenoud, E. Negri, C. La Vecchia, Cancer mortality in Europe, 2005-2009, and an overview of trends since 1980. Ann. Oncol. 24, 2657–2671 (2013). https://doi.org/10.1093/annonc/mdt301

    CAS  Article  PubMed  Google Scholar 

  18. C.M. Kitahara, J.A. Sosa, The changing incidence of thyroid cancer. Nat. Rev. Endocrinol. 12, 646–653 (2016). https://doi.org/10.1038/nrendo.2016.110

    Article  PubMed  Google Scholar 

  19. N. Pandeya, D.S. McLeod, K. Balasubramaniam, P.D. Baade, P.H. Youl, C.J. Bain, R. Allison, S.J. Jordan, Increasing thyroid cancer incidence in Queensland, Australia 1982-2008 - True increase or overdiagnosis. Clin. Endocrinol. (Oxf.). 84, 257–264 (2016). https://doi.org/10.1111/cen.12724

    CAS  Article  PubMed  Google Scholar 

  20. L. Davies, Overdiagnosis of thyroid cancer. BMJ 355, i6312 (2016).

    Article  Google Scholar 

  21. S. Vaccarella, S. Franceschi, F. Bray, C.P. Wild, M. Plummer, L. Dal Maso, Worldwide Thyroid-Cancer Epidemic? The increasing impact of overdiagnosis. N. Engl. J. Med. 375, 614–617 (2016). https://doi.org/10.1056/NEJMp1604412

    Article  PubMed  Google Scholar 

  22. H.G. Welch, W.C. Black, Overdiagnosis in cancer. J. Natl. Cancer Inst. 102, 605–613 (2010). https://doi.org/10.1093/jnci/djq099

    Article  PubMed  Google Scholar 

  23. R. De Angelis, M. Sant, M.P. Coleman, S. Francisci, P. Baili, D. Pierannunzio, A. Trama, O. Visser, H. Brenner, E. Ardanaz, M. Bielska-Lasota, G. Engholm, A. Nennecke, S. Siesling, F. Berrino, R. Capocaccia, EUROCARE-5 Working Group: Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE-5-a population-based study. Lancet Oncol. 15, 23–34 (2014). https://doi.org/10.1016/S1470-2045(13)70546-1

    Article  PubMed  Google Scholar 

  24. WHO: World Health Organization. International statistical classification of diseases and related health problems. 10th revision. Geneva. (1992)

  25. A. Fritz, C. Percy, A., Jack, K. Shanmugaratnam, L.H. Sobin, M.D. Parkin, C. WHO, Percy, V. Van, Holten,C. Muir: International Classification of Diseases for Oncology. 3rd ed., Geneva (2013)

  26. C. Percy, V.H. V, C. Muir. International classification of diseases for oncology. (World Health Organization, Geneva), 1990)

    Google Scholar 

  27. A. Harari, R.K. Singh, Increased rates of advanced thyroid cancer in California. J. Surg. Res. 201, 244–252 (2016). https://doi.org/10.1016/j.jss.2015.10.037

    Article  PubMed  Google Scholar 

  28. A. Safavi, F. Azizi, R. Jafari, S. Chaibakhsh, A.A. Safavi, Thyroid cancer epidemiology in Iran: A time trend study. Asian Pacific. J. Cancer Prev. 17, 407–412 (2016). https://doi.org/10.7314/APJCP.2016.17.1.407

    Article  Google Scholar 

  29. L. Keinan-Boker, B.G. Silverman, Trends of thyroid cancer in Israel: 1980–2012. Rambam Maimonides Med. J. 7, e0001 (2016). https://doi.org/10.5041/RMMJ.10228

    Article  PubMed Central  Google Scholar 

  30. M. Colonna, Z. Uhry, A.V. Guizard, P. Delafosse, C. Schvartz, A. Belot, P. Grosclaude, F. network, Recent trends in incidence, geographical distribution, and survival of papillary thyroid cancer in France. Cancer Epidemiol. 39, 511–518 (2015). https://doi.org/10.1016/j.canep.2015.04.015

    CAS  Article  PubMed  Google Scholar 

  31. H. Lim, S.S. Devesa, J.A. Sosa, D. Check, C.M. Kitahara, D.M. L, Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013. JAMA 317, 1338 (2017). https://doi.org/10.1001/jama.2017.2719

    Article  PubMed  Google Scholar 

  32. J. Lukas, J. Drabek, D. Lukas, L. Dusek, J. Gatek, The epidemiology of thyroid cancer in the Czech Republic in comparison with other countries. Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc Czech. Repub. 157, 266–275 (2013). https://doi.org/10.5507/bp.2012.086

    Article  PubMed  Google Scholar 

  33. J.R. Burgess, Temporal trends for thyroid carcinoma in Australia: an increasing incidence of papillary thyroid carcinoma (1982-1997). Thyroid 12, 141–149 (2002). https://doi.org/10.1089/105072502753522374

    Article  PubMed  Google Scholar 

  34. T. Hakala, P. Kellokumpu-Lehtinen, I. Kholová, K. Holli, H. Huhtala, J. Sand, Rising incidence of small size papillary thyroid cancers with no change in disease-specific survival in finnish thyroid cancer patients. Scand. J. Surg. 101, 301–306 (2012). https://doi.org/10.1177/145749691210100415

    CAS  Article  PubMed  Google Scholar 

  35. C. La Vecchia, C. Bosetti, F. Lucchini, P. Bertuccio, E. Negri, P. Boyle, F. Levi, Cancer mortality in Europe, 2000-2004, and an overview of trends since 1975. Ann. Oncol. 21, 1323–1360 (2009). https://doi.org/10.1093/annonc/mdp530

    Article  PubMed  Google Scholar 

  36. R.M. Reynolds, J. Weir, D.L. Stockton, D.H. Brewster, T.C. Sandeep, M.W.J. Strachan, Changing trends in incidence and mortality of thyroid cancer in Scotland. Clin. Endocrinol. (Oxf.). 62, 156–162 (2005). https://doi.org/10.1111/j.1365-2265.2004.02187.x

    Article  PubMed  Google Scholar 

  37. J.H. Lubin, M.J. Adams, R. Shore, E. Holmberg, A.B. Schneider, M.M. Hawkins, L.L. Robison, P.D. Inskip, M. Lundell, R. Johansson, R.A. Kleinerman, F. de Vathaire, L. Damber, S. Sadetzki, M. Tucker, R. Sakata, L.H.S. Veiga, Thyroid cancer following childhood low dose radiation exposure: a pooled analysis of nine cohorts. J. Clin. Endocrinol. Metab. 102(7), 2575–2583 (2017). https://doi.org/10.1210/jc.2016-3529

    Article  PubMed  PubMed Central  Google Scholar 

  38. K.B. Moysich, R.J. Menezes, A.M. Michalek, Chernobyl-related ionising radiation exposure and cancer risk: an epidemiological review. Lancet Oncol. 3, 269–279 (2002). https://doi.org/10.1016/S1470-2045(02)00727-1

    Article  PubMed  Google Scholar 

  39. UNSCEAR: UNSCEAR 2008 Report. Sources and Effects of Ionizing Radiation, United Nations Scientific Committee on the Effects of Atomic Radiation. Report to the General Assembly, with Scientific Annexes. (2008)

  40. Y. Liu, L. Su, H. Xiao, Review of factors related to the thyroid cancer epidemic. Int. J. Endocrinol. 2017, 1–9 (2017). https://doi.org/10.1155/2017/5308635

    CAS  Article  Google Scholar 

  41. L. Dal Maso, C. Bosetti, C. La Vecchia, S. Franceschi, Risk factors for thyroid cancer: An epidemiological review focused on nutritional factors. Cancer Causes Control 20, 75–86 (2009). https://doi.org/10.1007/s10552-008-9219-5

    Article  PubMed  Google Scholar 

  42. R. Zamora-Ros, S. Rinaldi, K.K. Tsilidis, E. Weiderpass, M.C. Boutron-Ruault, A.L. Rostgaard-Hansen, A. Tjønneland, F. Clavel-Chapelon, S. Mesrine, V.A. Katzke, T. Kühn, J. Förster, H. Boeing, A. Trichopoulou, P. Lagiou, E. Klinaki, G. Masala, S. Sieri, F. Ricceri, R. Tumino, A. Mattiello, P.H.M. Peeters, H.B. Bueno-De-Mesquita, D. Engeset, G. Skeie, M. Argüelles, A. Agudo, M.J. Sánchez, M.D. Chirlaque, A. Barricarte, S. Chamosa, M. Almquist, A. Tosovic, J. Hennings, M. Sandström, J.A. Schmidt, K.T. Khaw, N.J. Wareham, A.J. Cross, N. Slimani, G. Byrnes, I. Romieu, E. Riboli, S. Franceschi, Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition study. Int. J. Cancer 138, 65–73 (2016). https://doi.org/10.1002/ijc.29693

    CAS  Article  PubMed  Google Scholar 

  43. E. Peterson, P. De, R. Nuttall, BMI, diet and female reproductive factors as risks for thyroid cancer: a systematic review. PLoS One 7, e29177 (2012). https://doi.org/10.1371/journal.pone.0029177

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  44. R. Zamora-Ros, J. Castañeda, S. Rinaldi, V. Cayssials, N. Slimani, E. Weiderpass, K.K. Tsilidis, M.-C. Boutron-Ruault, K. Overvad, A.K. Eriksen, A. Tjønneland, T. Kühn, V. Katzke, H. Boeing, A. Trichopoulou, C. La Vecchia, A. Kotanidou, D. Palli, S. Grioni, A. Mattiello, R. Tumino, V. Sciannameo, E. Lund, S. Merino, E. Salamanca-Fernández, P. Amiano, J.M. Huerta, A. Barricarte, U. Ericson, M. Almquist, J. Hennings, M. Sandström, H.B. Bueno-de-Mesquita, P.H. Peeters, K.-T. Khaw, N.J. Wareham, J.A. Schmidt, A.J. Cross, E. Riboli, A. Scalbert, I. Romieu, A. Agudo, S. Franceschi, Consumption of Fish Is Not Associated with Risk of Differentiated Thyroid Carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. J. Nutr. 147, 1366–1373 (2017). https://doi.org/10.3945/jn.117.247874

    CAS  Article  PubMed  Google Scholar 

  45. R. Zamora-Ros, V. Béraud, S. Franceschi, V. Cayssials, K.K. Tsilidis, M.C. Boutron-Ruault, E. Weiderpass, K. Overvad, A. Tjønneland, A.K. Eriksen, F. Bonnet, A. Affret, V. Katzke, T. Kühn, H. Boeing, A. Trichopoulou, E. Valanou, A. Karakatsani, G. Masala, S. Grioni, M. Santucci de Magistris, R. Tumino, F. Ricceri, G. Skeie, C.L. Parr, S. Merino, E. Salamanca-Fernández, M.D. Chirlaque, E. Ardanaz, P. Amiano, M. Almquist, I. Drake, J. Hennings, M. Sandström, H.B. Bueno-de-Mesquita, P.H. Peeters, K.T. Khaw, N.J. Wareham, J.A. Schmidt, A. Perez-Cornago, D. Aune, E. Riboli, N. Slimani, A. Scalbert, I. Romieu, A. Agudo, S. Rinaldi, Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Int. J. Cancer 142, 449–459 (2018). https://doi.org/10.1002/ijc.30880

    CAS  Article  PubMed  Google Scholar 

  46. M. Han, J. Kim, Coffee consumption and the risk of thyroid cancer: a systematic review and meta-analysis. Int. J. Environ. Res. Public Health 14, 129 (2017). https://doi.org/10.3390/ijerph14020129

    CAS  Article  PubMed Central  Google Scholar 

  47. A. Sen, K.K. Tsilidis, N.E. Allen, S. Rinaldi, P.N. Appleby, M. Almquist, J.A. Schmidt, C.C. Dahm, K. Overvad, A. Tjønneland, A.L. Rostgaard-Hansen, F. Clavel-Chapelon, L. Baglietto, M.-C. Boutron-Ruault, T. Kühn, V.A. Katze, H. Boeing, A. Trichopoulou, C. Tsironis, P. Lagiou, D. Palli, V. Pala, S. Panico, R. Tumino, P. Vineis, H.A. Bueno-de-Mesquita, P.H. Peeters, A. Hjartåker, E. Lund, E. Weiderpass, J.R. Quirós, A. Agudo, M.-J. Sánchez, L. Arriola, D. Gavrila, A.B. Gurrea, A. Tosovic, J. Hennings, M. Sandström, I. Romieu, P. Ferrari, R. Zamora-Ros, K.-T. Khaw, N.J. Wareham, E. Riboli, M. Gunter, S. Franceschi, Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study. Br. J. Cancer 113, 840–847 (2015). https://doi.org/10.1038/bjc.2015.280

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  48. S.-H. Hong, S.-K. Myung, H.S. Kim, Korean Meta-Analysis (KORMA) Study Group: alcohol intake and risk of thyroid cancer: a meta-analysis of observational studies. Cancer Res. Treat. 49, 534–547 (2017). https://doi.org/10.4143/crt.2016.161

    Article  PubMed  Google Scholar 

  49. S. Rinaldi, M. Lise, F. Clavel-Chapelon, M.-C.C. Boutron-Ruault, G. Guillas, K. Overvad, A. Tjønneland, J. Halkjær, A. Lukanova, R. Kaaks, M.M. Bergmann, H. Boeing, A. Trichopoulou, D. Zylis, E. Valanou, D. Palli, C. Agnoli, R. Tumino, S. Polidoro, A. Mattiello, H.B. Bueno-de-Mesquita, P.H. Peeters, E. Weiderpass, E. Lund, G. Skeie, L. Rodríguez, N. Travier, M.-J.J. Sánchez, P. Amiano, J.-M.M. Huerta, E. Ardanaz, T. Rasmuson, G. Hallmans, M. Almquist, J. Manjer, K.K. Tsilidis, N.E. Allen, K.-T.T. Khaw, N. Wareham, G. Byrnes, I. Romieu, E. Riboli, S. Franceschi, H. Bas Bueno-De-Mesquita, P.H. Peeters, E. Weiderpass, E. Lund, G. Skeie, L. Rodríguez, N. Travier, M.-J.J. Sánchez, P. Amiano, J.-M.M. Huerta, E. Ardanaz, T. Rasmuson, G. Hallmans, M. Almquist, J. Manjer, K.K. Tsilidis, N.E. Allen, K.-T.T. Khaw, N. Wareham, G. Byrnes, I. Romieu, E. Riboli, S: Franceschi, Body size and risk of differentiated thyroid carcinomas: Findings from the EPIC study. Int. J. Cancer 131, 1004–1014 (2012). https://doi.org/10.1002/ijc.27601

    CAS  Article  Google Scholar 

  50. R. Zamora-Ros, S. Rinaldi, C. Biessy, A. Tjønneland, J. Halkjær, A. Fournier, M.C. Boutron-Ruault, S. Mesrine, K. Tikk, R.T. Fortner, H. Boeing, J. Förster, A. Trichopoulou, D. Trichopoulos, E.M. Papatesta, G. Masala, G. Tagliabue, S. Panico, R. Tumino, S. Polidoro, P.H.M. Peeters, H.B. Bueno-De-Mesquita, E. Weiderpass, E. Lund, M. Argüelles, A. Agudo, E. Molina-Montes, C. Navarro, A. Barricarte, N. Larrañaga, J. Manjer, M. Almquist, M. Sandström, J. Hennings, K.K. Tsilidis, J.A. Schmidt, K.T. Khaw, N.J. Wareham, I. Romieu, G. Byrnes, M.J. Gunter, E. Riboli, S. Franceschi, Reproductive and menstrual factors and risk of differentiated thyroid carcinoma: The EPIC study. Int. J. Cancer 136, 1218–1227 (2015). https://doi.org/10.1002/ijc.29067

    CAS  Article  PubMed  Google Scholar 

  51. J. Zhu, X. Zhu, C. Tu, Y.-Y. Li, K.-Q. Qian, C. Jiang, T.-B. Feng, C. Li, G.J. Liu, L. Wu, Parity and thyroid cancer risk: a meta-analysis of epidemiological studies. Cancer Med. 5, 739–752 (2016). https://doi.org/10.1002/cam4.604

    Article  PubMed  Google Scholar 

  52. X. Yi, J. Zhu, X. Zhu, G. J. Liu, L. Wu, Breastfeeding and thyroid cancer risk in women: a dose responsemeta-analysis of epidemiological studies. Clin. Nutr. 35, 1039–1046 (2015). https://doi.org/10.1016/j.clnu.2015.12.005

    Article  Google Scholar 

  53. S. Shin, N. Sawada, E. Saito, T. Yamaji, M. Iwasaki, T. Shimazu, S. Sasazuki, M. Inoue, S. Tsugane, Menstrual and reproductive factors in the risk of thyroid cancer in Japanese women. Eur. J. Cancer Prev. 27, 361–369 (2018). https://doi.org/10.1097/CEJ.0000000000000338

    Article  Google Scholar 

  54. Q.T. Nguyen, E.J. Lee, M.G. Huang, Y.I. Park, A. Khullar, R.A. Plodkowski, Diagnosis and treatment of patients with thyroid cancer. Am. Heal. Drug Benefits 8, 30–40 (2015)

    Google Scholar 

  55. L.G.T. Morris, R.M. Tuttle, L. Davies, Changing Trends in the Incidence of Thyroid Cancer in the United States. JAMA Otolaryngol. Neck Surg. 142, 709 (2016). https://doi.org/10.1001/jamaoto.2016.0230

    Article  Google Scholar 

  56. Y.J. Cho, D.Y. Kim, E.-C. Park, K.-T. Han, Thyroid fine-needle aspiration biopsy positively correlates with increased diagnosis of thyroid cancer in South Korean patients. BMC Cancer 17, 114 (2017). https://doi.org/10.1186/s12885-017-3104-0

    Article  PubMed  PubMed Central  Google Scholar 

  57. C. Saint-Martin, M. Dramé, S. Dabakuyo, L. Kanagaratnam, P. Arveux, C. Schvartz, Overdiagnosis of thyroid cancer in the Marne and Ardennes Departments of France from 1975 to 2014. Ann. Endocrinol. (Paris) 78, 27–32 (2017). https://doi.org/10.1016/j.ando.2016.07.005

    Article  Google Scholar 

  58. J. Zagzag, A. Kenigsberg, K.N. Patel, K.S. Heller, J.B. Ogilvie, Thyroid cancer is more likely to be detected incidentally on imaging in private hospital patients. J. Surg. Res. 215, 239–244 (2017). https://doi.org/10.1016/j.jss.2017.03.059

    Article  PubMed  Google Scholar 

  59. L. Enewold, K. Zhu, E. Ron, A.J. Marrogi, A. Stojadinovic, G.E. Peoples, S.S. Devesa, Rising Thyroid Cancer Incidence in the United States by Demographic and Tumor Characteristics, 1980-2005. Cancer Epidemiol. Biomark. Prev. 18, 784–791 (2009). https://doi.org/10.1158/1055-9965.EPI-08-0960

    Article  Google Scholar 

  60. B. Aschebrook-Kilfoy, R.H. Grogan, Overdiagnosis of Thyroid Cancer and Graves’ Disease. Thyroid 24, 403–404 (2014). https://doi.org/10.1089/thy.2013.0584

    Article  PubMed  Google Scholar 

  61. M. Garcia-Talavera, J.L. Matarranz, M. Martinez, R. Salas, L. Ramos, Natural ionizing radiation exposure of the Spanish population. Radiat. Prot. Dosimetry 124, 353–359 (2007). https://doi.org/10.1093/rpd/ncm213

    CAS  Article  PubMed  Google Scholar 

  62. F. Soriguer, E. García-Fuentes, C. Gutierrez-Repiso, G. Rojo-Martínez, I. Velasco, A. Goday, A. Bosch-Comas, E. Bordiú, A. Calle, R. Carmena, R. Casamitjana, L. Castaño, C. Castell, M. Catalá, E. Delgado, J. Franch, S. Gaztambide, J. Girbés, R. Gomis, G. Gutiérrez, A. López-Alba, M.T. Martínez-Larrad, E. Menéndez, I. Mora-Peces, E. Ortega, G. Pascual-Manich, M. Serrano-Rios, S. Valdés, J.A. Vázquez, J. Vendrell, Iodine intake in the adult population. Di@Bet. es Study. Clin. Nutr. 31(6), 882–888 (2012).https://doi.org/10.1016/j.clnu.2012.04.004

    CAS  Article  PubMed  Google Scholar 

  63. K.L. Caldwell, A. Makhmudov, E. Ely, R.L. Jones, R.Y. Wang, Iodine Status of the U.S. Population, National Health and Nutrition Examination Survey, 2005–2006 and 2007–2008. Thyroid 21, 419–427 (2011).https://doi.org/10.1089/thy.2010.0077

    Article  PubMed  Google Scholar 

  64. B. De Benoist, M. Andersson, I. Egli, B. Takkouche, H. Allen.: Iodine status worldwide: WHO Global Database on Iodine Deficiency. (2005) pp 9–16

  65. L. Pagano, C. Mele, D. Arpaia, M.T. Samà, M. Caputo, S. Ippolito, C. Peirce, F. Prodam, G. Valente, G. Ciancia, G. Aimaretti, B. Biondi, How do etiological factors can explain the different clinical features of patients with differentiated thyroid cancer and their histopathological findings? Endocrine 56, 129–137 (2017). https://doi.org/10.1007/s12020-016-0992-8

    CAS  Article  PubMed  Google Scholar 

  66. L. Davies, M.H.G. Welch, Increasing incidence of thyroid cancer in the united states, 1973-2002. J. Am. Med. Assoc. 295, 2164–2167 (2006). https://doi.org/10.1001/jama.295.18.2164

    CAS  Article  Google Scholar 

  67. J.P. Zevallos, C.M. Hartman, J.R. Kramer, E.M. Sturgis, E.Y. Chiao, Increased thyroid cancer incidence corresponds to increased use of thyroid ultrasound and fine-needle aspiration: a study of the veterans affairs health care system. Cancer 121, 741–746 (2015). https://doi.org/10.1002/cncr.29122

    Article  PubMed  Google Scholar 

  68. R. Udelsman, Y. Zhang, The epidemic of thyroid cancer in the United States: the role of endocrinologists and ultrasounds. Thyroid 24, 472–479 (2014). https://doi.org/10.1089/thy.2013.0257

    Article  PubMed  PubMed Central  Google Scholar 

  69. L. Davies, H.G. Welch, Current Thyroid Cancer Trends in the United States. JAMA Otolaryngol. Neck Surg. 140, 317 (2014). https://doi.org/10.1001/jamaoto.2014.1

    Article  Google Scholar 

  70. L.G.T. Morris, A.G. Sikora, T.D. Tosteson, L. Davies, The increasing incidence of thyroid cancer: the influence of access to care. Thyroid 23, 885–891 (2013). https://doi.org/10.1089/thy.2013.0045

    Article  PubMed  PubMed Central  Google Scholar 

  71. R. Etzioni, D.F. Penson, J.M. Legler, D. di Tommaso, R. Boer, P.H. Gann, E.J. Feuer, Overdiagnosis due to prostate-specific antigen screening: lessons from U.S. prostate cancer incidence trends. J. Natl. Cancer Inst. 94, 981–990 (2002)

    Article  Google Scholar 

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Acknowledgements

We thank Granada Cancer Registry workers for their job collecting these data.

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Authors and Affiliations

  1. Andalusian School of Public Health (EASP), Granada, Spain

    Elena Salamanca-Fernández, Miguel Rodriguez-Barranco, Yoe-Ling Chang-Chan, Daniel Redondo-Sánchez & María José Sánchez

  2. CIBER Epidemiology and Public Health (CIBERESP), Granada, Spain

    Elena Salamanca-Fernández, Miguel Rodriguez-Barranco & María José Sánchez

  3. Biosanitary Investigation Institute ibs, Granada, Spain

    Elena Salamanca-Fernández, Miguel Rodriguez-Barranco, Yoe-Ling Chang-Chan, Daniel Redondo-Sánchez, José Expósito & María José Sánchez

  4. University Hospital Virgen de las Nieves Granada, Granada, Spain

    Santiago Domínguez-López

  5. Radiation Oncology Department, University Hospital Virgen Macarena, Sevilla, Spain

    Eloísa Bayo

  6. Preventive Medicine and Public Health Department, Hospital Virgen de la Victoria of Málaga, Málaga, Spain

    Dariusz Narankiewicz

  7. Radiotherapy and Oncology Department, University Hospital Virgen de las Nieves Granada, Granada, Spain

    José Expósito

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  1. Elena Salamanca-Fernández
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  2. Miguel Rodriguez-Barranco
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  5. Santiago Domínguez-López
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  7. Dariusz Narankiewicz
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  9. María José Sánchez
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Correspondence to Miguel Rodriguez-Barranco.

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This article does not contain any studies with human participants or animals performed by any of the authors. This study is based on secondary administrative data.

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Salamanca-Fernández, E., Rodriguez-Barranco, M., Chang-Chan, YL. et al. Thyroid Cancer Epidemiology in South Spain: a population-based time trend study. Endocrine 62, 423–431 (2018). https://doi.org/10.1007/s12020-018-1681-6

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  • DOI: https://doi.org/10.1007/s12020-018-1681-6

Keywords

  • Thyroid cancer
  • Incidence
  • Mortality
  • Epidemiology
  • Trends
  • Sex differences