Impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the risk of malignancy estimated by the ultrasonographic classification of the American Thyroid Association (ATA) in thyroid nodules >1 cm
- 102 Downloads
Recently, it was proposed that the noninvasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) should no longer be considered “cancer” rather referred to as “noninvasive follicular thyroid neoplasm with papillary-like nuclear features” (NIFTP) . Since this neoplasm accounts for up to 20% of all PTC , the change alters the frequency of malignancy in thyroid nodules obtained while EFVPTC was still considered “cancer”. The impact of this change has been widely studied in terms of the result of cytology, with a significant reduction in the risk of malignancy in nodules with indeterminate cytology or suspicion for PTC after the exclusion of NIFTP . On the other hand, to our knowledge, no study has so far reevaluated the risk of malignancy according to the ultrasonographic appearance of the nodule after the exclusion of NIFTP.
In a prospective study of 1502 nodules , we previously evaluated the risk of malignancy in thyroid nodules >1 cm for...
This work was supported by the Brazilian National Council for Scientific and Technological Development (CNPq).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The study was approved by the Research Ethics Committee of our institution.
Informed consent was obtained from all individual participants included in the study.