Impact of subclinical hypothyroidism with TSH ≤10 mIU/L on glomerular filtration rate in adult women without known kidney disease
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Subclinical hypothyroidism (SCH) is a common condition in adults, especially in women. Although not considered by current guidelines in the treatment decision of SCH [1, 2, 3, 4, 5], concern exists regarding the association with decreased glomerular filtration rate (GFR). However, in the absence of overt hypothyroidism (TSH >20 mIU/L or low T4), TSH elevation might be a consequence of decreased GFR and does not reflect true thyroid dysfunction [1, 6]. Although SCH has a negative impact on GFR, this has been suggested particularly in patients with established kidney disease [7, 8, 9, 10, 11, 12] or associated conditions that are also known to compromise renal function, such as diabetes mellitus and arterial hypertension [7, 8, 10, 13]. The repercussion of SCH on GFR in adults without known kidney disease or risk conditions for renal dysfunction is less studied .
A reasonable consensus on the need for treatment exists for individuals with SCH and TSH >10 mIU/L, except for...
This work was supported by the Brazilian National Council for Scientific and Technological Development (CNPq).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Research involving human participants
The study was approved by the local Research Ethics Committee and the subjects gave written informed consent.
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