Adiponectin and vitamin D-binding protein are independently associated at birth in both mothers and neonates
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Adult body fat is associated with birth anthropometry, suggesting a role for metabolic regulators including vitamin D and the adipokines—adiponectin and irisin—which have been reported to interact but, as yet, data remain controversial.
To study (i) the relationship between vitamin D, its binding protein (VDBP) and the adipokines, adiponectin, and irisin in mothers and neonates at birth and (ii) their effects on neonate anthropometric outcomes.
Cross-sectional study for healthy mothers with full-term and uncomplicated births.
Seventy pairs of newly delivered neonates and their mothers.
Main outcomes features
Biochemical markers from maternal and cord: VDBP, adiponectin, irisin, calcium, albumin, parathyroid hormone, 25OHD, 1,25(OH)2D. Maternal demographic and social characteristics and neonate anthropometric parameters were recorded.
Maternal VDBP levels (364.1 ± 11.9 μg/ml) demonstrated a strong positive correlation with maternal adiponectin (4.4 ± 0.4 μg/ml) and irisin (308.8 ± 50.8 ng/ml) concentrations, which remained significant (p < 0.001 and p < 0.041, respectively) after adjustment with multiple parameters, including weeks of gestation, maternal age, and BMI. The finding of a strong association of VDBP (355.3 ± 29.2 μg/ml) and adiponectin (11.9 ± 2.0 μg/ml) but not irisin (174.4 ± 26.0 ng/ml) was also evident in neonates (p = 0.03 and p = 0.94, respectively). No association was observed in both maternal and neonatal vitamin D, adiponectin, and irisin.
The main findings of this study are (i) the perspective of a potential independent interaction of VDBP and adiponectin in both mothers and neonates and (ii) the lack of a causative model effect of both maternal/neonatal vitamin D status and adipokine profile on neonatal anthropometry at birth, as a surrogate marker of future metabolic health of the offspring.
KeywordsAdipokines Adiponectin Irisin Neonates Vitamin D Vitamin D-binding protein
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
- 7.L.L. Ritterhouse, R. Lu, H.B. Shah, J.M. Robertson, D.A. Fife, H.T. Maecker, H. Du, C.G. Fathman, E.F. Chakravarty, R.H. Scofield, D.L. Kamen, J.M. Guthridge, J.A. James, Vitamin d deficiency in a multiethnic healthy control cohort and altered immune response in vitamin D deficient European-American healthy controls. PLoS ONE 9(4), e94500 (2014)CrossRefPubMedPubMedCentralGoogle Scholar
- 9.J.L. Jackson, S.E. Judd, B. Panwar, V.J. Howard, V.G. Wadley, N.S. Jenny, O.M. Gutiérreza, Associations of 25-hydroxyvitamin D with markers of inflammation, insulin resistance and obesity in black and white community-dwelling adults. J. Clin. Trans. Endocrinol. 5, 21–25 (2016)Google Scholar
- 12.M. Grammatiki, E. Rapti, S. Karras, R.A. Ajjan, K. Kotsa, Vitamin D and diabetes mellitus: causal or casual association? Rev. Endocr. Metab. Disord. https://doi.org/10.1007/s11154-016-9403-y (2017).
- 14.L.J. Black, D. Anderson, M.W. Clarke, A.L. Ponsonby, R.M. Lucas, Ausimmune Investigator Group, Analytical bias in the measurement of serum 25-hydroxyvitamin D concentrations impairs assessment of vitamin D status in clinical and research settings. PLoS ONE 10, e0135478 (2015)CrossRefPubMedPubMedCentralGoogle Scholar
- 19.M. Dinca, M.C. Serban, A. Sahebkar, D.P. Mikhailidis, P.P. Toth, S.S. Martin, M.J. Blaha, M. Blüher, C. Gurban, P. Penson, E.D. Michos, A.V. Hernandez, S.R. Jones, M. Banach; for Lipid Blood Pressure Meta-analysis Collaboration LBPMC Group, Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials. Pharmacol. Res. 107, 360–371 (2016)CrossRefPubMedGoogle Scholar
- 22.N.M. Al-Daghri, S. Rahman, S. Sabico, O.E. Amer, K. Wani, O.S. Al-Attas, M.S. Alokail, Impact of vitamin D correction on circulating irisin: a 12 month interventional study. Int J. Clin. Exp. Med. 9(7), 13086–13092 (2016)Google Scholar
- 23.J. Simpson, A.D. Smith, A. Fraser, N. Sattar, R.S. Lindsay, S.M. Ring, K. Tilling, G. Davey Smith, D.A. Lawlor, S.M. Nelson, Programming of adiposity in childhood and adolescence: associations with birth weight and cord blood adipokines. J. Clin. Endocrinol. Metab. 102(2), 499–506 (2017)PubMedGoogle Scholar
- 25.J.D. Keeping. Determinants and Components of Size at Birth (University of Aberdeen, Scotland, 1981)Google Scholar
- 26.Calcium, Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D, A.C. Ross, C.L. Taylor, A.L. Yaktine, H.B. Del Valle, Dietary Reference Intakes for Calcium and Vitamin D. Dietary Reference Intakes for Calcium and Vitamin D (National Academies Press (US), Washington, DC, 2011)Google Scholar
- 35.Z.C. Luo, A.M. Nuyt, E. Delvin, W.D. Fraser, P. Julien, F. Audibert, I. Girard, B. Shatenstein, C. Deal, E. Grenier, C. Garofalo, E. Levy, Maternal and fetal leptin, adiponectin levels and associations with fetal insulin sensitivity. Obesity (Silver Spring). 21(1), 210–216 (2013)CrossRefPubMedGoogle Scholar
- 38.C.L. Wagner, B.W. Hollis, K. Kotsa, H. Fakhoury, S.N. Karras, Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications. Rev. Endocr. Metab. Disord. (2017). https://doi.org/10.1007/s11154-017-9414-3
- 42.S.N. Karras, I. Shah, A. Petroczi, D.G. Goulis, H. Bili, F. Papadopoulou, V. Harizopoulou, B.C. Tarlatzis, D.P. Naughton, An observational study reveals that neonatal vitamin D is primarily determined by maternal contributions: implications of a new assay on the roles of vitamin D forms. Nutr. J. 12, 77 (2013)CrossRefPubMedPubMedCentralGoogle Scholar