Association of obesity and diabetes with thyroid nodules
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There are conflicting data concerning the possibility that obesity and diabetes raise the risk of thyroid nodules. The incidence of thyroid nodules is increasing, as is that of obesity and diabetes; therefore, understanding whether these metabolic and nutritional disorders influence nodular thyroid disease is important for organizing prevention strategies. This study investigated the association between thyroid nodules, obesity, diabetes, and dietary habits.
Materials and methods
A cohort of randomly selected adults (455 males, 746 females; age: 18–90 years) living in Palermo (Italy), a mild iodine deficiency area, was cross-sectionally investigated. Participants underwent high-resolution ultrasonographic evaluation of the thyroid, and answered a food frequency questionnaire. Laboratory blood measurements were obtained in 587 participants.
Results and discussion
Thyroid nodules were detected in 475 (39.5%) participants. The number of thyroid nodules was correlated with age (r = 0.19; P < 0.001), gender (r = 0.08; P = 0.005), and body mass index (r = 0.07; P = 0.02). No significant correlation was observed between the number of nodules and glycated hemoglobin, serum insulin concentrations, and homeostasis model assessment of insulin resistance. Age-adjusted and gender-adjusted prevalence of both overweight/obesity and type 2 diabetes of each group of participants divided according to the number of nodules significantly increased with the number of nodules (P < 0.05 in both cases). The group of participants with nodules exhibited a significantly lower age-adjusted and gender-adjusted habitual intake of milk (P = 0.02). Multivariate regression analysis showed that age, gender, body mass index, diabetes, and habitual consumption of milk were independently correlated with presence of thyroid nodules.
This study seems to indicate that an association exists between obesity, diabetes, and thyroid nodules.
KeywordsThyroid nodules Obesity Diabetes Milk Diet
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all participants included in the study.
- 2.B. D’Avanzo, C. La Vecchia, S. Franceschi, E. Negri, R. Talamini, History of thyroid diseases and subsequent thyroid cancer risk. Cancer Epidemiol. Biomark. Prev. 4, 193–199 (1995)Google Scholar
- 15.M. Finucane, G. Stevens, M. Cowan, G. Danaei, J.K. Lin, C.J. Paciorek et al.. National, regional and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 377, 567–577 (2011). doi: 10.1016/S0140-6736(10)62037-5 Google Scholar
- 18.C.S. Fox, M.J. Pencina, R.B. D’Agostino, J.M. Murabito, E.W. Seely, E.N. Pearce et al.. Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. Arch. Intern. Med. 168, 587–592 (2008). doi: 10.1001/archinte.168.6.587 CrossRefPubMedGoogle Scholar
- 19.N. Custro, V. Scafidi, M.C. De Francisci, S. Buscemi, Hormones of the pituitary-thyroid axis in obese subjects on free and low-calorie diet. Clin. Ther. 120, 199–203 (1987)Google Scholar
- 24.S. Buscemi, A. Nicolucci, A. Mattina, G. Rosafio, F.M. Massenti, G. Lucisano et al. Association of dietary patterns with insulin resistance and clinically silent carotid atherosclerosis in apparently healthy people. Eur. J. Clin. Nutr. 67, 1284–1290 (2013). doi: 10.1038/ejcn.2013.172 CrossRefPubMedGoogle Scholar
- 27.WHO. (2016). Obesity and overweight. http://apps.who.int/bmi/index.jsp?introPage=intro_3.html. Accessed 27th Jun 2017
- 31.ISTAT. Statistiche demografiche Palermo. http://www.tuttitalia.it/sicilia/81-palermo/statistiche/popolazione-eta-sesso-stato-civile-2015. Accessed 18 Dec 2015
- 32.S. Buscemi, G. Geraci, F.M. Massenti, C. Buscemi, F. Costa, C. D’Orio, G. Rosafio, C. Buscemi, V. Maniaci, G. Parrinello, Renal function and carotid atherosclerosis in adults with no known kidney disease. Nutr. Metab. Cardiovasc. Dis. 27, 267–273 (2017). doi: 10.1016/j.numecd.2016.09.013 CrossRefPubMedGoogle Scholar
- 34.Corsaro, L., Falco, V., Venturi, F., Dotta, F., Frontoni, S., Lauro, D., et al. (2015). Analysis of the diabetes in Italy. The Italian Barometer Diabetes Observatory. http://www.ibdo.it/pdf/diabetesmonitor2015n2.pdf. Accessed 30 Dec 2015
- 35.ISTAT. Obesità e sovrappeso. http://www3.istat.it/salastampa/comunicati/non_calendario/20010313_00/. Accessed 30 Dec 2015
- 39.Buscemi, S., Nicolucci, A., Lucisano, G., Mattina, A., Rosafio, G., Barile, A.M., et al. (2014). Stile di vita e prevalenza di obesità, ipertensione e diabete in un campione di bambini, adolescenti e adulti. Lo studio ABCD. Proceedings of the 25th National Congress of the Italian Society of Diabetology, BolognaGoogle Scholar