Skip to main content

Advertisement

SpringerLink
Log in

Gain-of-function SNPs in NLRP3 and IL1B genes confer protection against obesity and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis?

  • Research Letter
  • Published:
Endocrine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. L.P. Zambetti, A. Mortellaro, NLRPs, microbiota, and gut homeostasis: unravelling the connection. J. Pathol. 233(4), 321–330 (2014)

    Article  CAS  PubMed  Google Scholar 

  2. M. Haneklaus, L.A. O’Neill, NLRP3 at the interface of metabolism and inflammation. Immunol. Rev. 265(1), 53–62 (2015)

    Article  CAS  PubMed  Google Scholar 

  3. K. Esposito, A. Pontillo, M. Ciotola, C. Di Palo, E. Grella, G. Nicoletti, D. Giugliano, Weight loss reduces interleukin-18 levels in obese women. J. Clin. Endocrinol. Metab. 87(8), 3864–3866 (2002)

    Article  CAS  PubMed  Google Scholar 

  4. A. Satpathy, S. Ravindra, S. Thakur, S. Kulkarni, A. Porwal, S. Panda, Serum interleukin-1β in subjects with abdominal obesity and periodontitis. Obes. Res. Clin. Pract 9(5), 513–521 (2015)

    Article  PubMed  Google Scholar 

  5. K.M. Flegal, B.K. Kit, H. Orpana, B.I. Graubard, Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA 309(1), 71–82 (2013)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. S.M. Grundy, J.I. Cleeman, S.R. Daniels, K.A. Donato, R.H. Eckel, B.A. Franklin, D.J. Gordon, R.M. Krauss, P.J. Savage, S.C. Smith Jr, J.A. Spertus, F. Costa; American Heart A, National Heart L, Blood I, Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement. Circulation 112(17), 2735–2752 (2005)

    Article  PubMed  Google Scholar 

  7. Y. Zhong, A. Kinio, M. Saleh, Functions of NOD-like receptors in human diseases. Front. Immunol. 4, 333 (2013)

    Article  PubMed  PubMed Central  Google Scholar 

  8. A.J. Murphy, M.J. Kraakman, H.L. Kammoun, D. Dragoljevic, M.K. Lee, K.E. Lawlor, J.M. Wentworth, A. Vasanthakumar, M. Gerlic, L.W. Whitehead, L. DiRago, L. Cengia, R.M. Lane, D. Metcalf, J.E. Vince, L.C. Harrison, A. Kallies, B.T. Kile, B.A. Croker, M.A. Febbraio, S.L. Masters, IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome. Cell. Metab. 23(1), 155–164 (2016)

    Article  CAS  PubMed  Google Scholar 

  9. M.G. Netea, L.A. Joosten, The NLRP1-IL18 connection: a stab in the back of obesity-induced inflammation. Cell. Metab. 23(1), 6–7 (2016)

    Article  CAS  PubMed  Google Scholar 

  10. Y. Hitomi, M. Ebisawa, M. Tomikawa, T. Imai, T. Komata, T. Hirota, M. Harada, M. Sakashita, Y. Suzuki, N. Shimojo, Y. Kohno, K. Fujita, A. Miyatake, S. Doi, T. Enomoto, M. Taniguchi, N. Higashi, Y. Nakamura, M. Tamari, Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. J. Allergy. Clin. Immunol. 124(4), 779–785 (2009). e6

    Article  CAS  PubMed  Google Scholar 

  11. R. Stienstra, J.A. van Diepen, C.J. Tack, M.H. Zaki, F.L. van de Veerdonk, D. Perera, G.A. Neale, G.J. Hooiveld, A. Hijmans, I. Vroegrijk, S. van den Berg, J. Romijn, P.C. Rensen, L.A. Joosten, M.G. Netea, T.D. Kanneganti, Inflammasome is a central player in the induction of obesity and insulin resistance. Proc. Natl Acad. Sci. USA 108(37), 15324–15329 (2011)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. E. Elinav, J. Henao-Mejia, R.A. Flavell, Integrative inflammasome activity in the regulation of intestinal mucosal immune responses. Mucosal Immunol. 6(1), 4–13 (2013)

    Article  CAS  PubMed  Google Scholar 

  13. M. Levy, E. Blacher, Elinav E microbiome, metabolites and host immunity. Curr. Opin. Microbiol. 35, 8–15 (2016)

    Article  PubMed  Google Scholar 

  14. J. Hung, B.M. McQuillan, C.M. Chapman, P.L. Thompson, J.P. Beilby, Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance. Arterioscler. Thromb. Vasc. Biol. 25(6), 1268–1273 (2005)

    Article  CAS  PubMed  Google Scholar 

  15. M. Vijay-Kumar, A.T. Gewirtz, Is predisposition to NAFLD and obesity communicable? Cell. Metab. 15(4), 419–420 (2012)

    Article  CAS  PubMed  Google Scholar 

  16. C. Bing, Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity? Adipocyte 4(2), 149–152 (2015)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. J.1 Henao-Mejia, E. Elinav, C. Jin, L. Hao, W.Z. Mehal, T. Strowig, C.A. Thaiss, A.L. Kau, S.C. Eisenbarth, M.J. Jurczak, J.P. Camporez, G.I. Shulman, J.I. Gordon, H.M. Hoffman, R.A. Flavell, Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482(7384), 179–185 (2012)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Funding

This study was supported by Sao Paulo Research Foundation (FAPESP) (Grants numbers: 2015/23395-6;) and “Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico” (CNPq). A.P. is a recipient of a CNPq fellowship. J.M.R. was a recipient of a PIBIC Fellowship. V.N.C.L. is a recipient of a FAPESP-funded fellowship. D.L. is a recipient of a UFAM-funded PhD Fellowship.

Author information

Authors and Affiliations

  1. Laboratório de Imunogenética, Departamento of Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo (USP), São Paulo, SP, Brazil

    Juliana de Moraes Rodrigues, Dhemerson Souza de Lima, Vinicius N. C. Leal & Alessandra Pontillo

  2. Nucleo de Pos-Graduacao e Pesquisa—Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil

    Adriana A. Bosco

  3. Departmento de Farmacologia, Instituto de Biociencias, Universidade Estadual Paulista/UNESP, Botucatu, SP, Brazil

    Valeria Sandrim

Authors
  1. Juliana de Moraes Rodrigues
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dhemerson Souza de Lima
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Vinicius N. C. Leal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Adriana A. Bosco
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Valeria Sandrim
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alessandra Pontillo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alessandra Pontillo.

Ethics declarations

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

Research involved human participants. All procedures performed were in accordance with the ethical standards of the Institutional Review Board of the “Santa Casa de Belo Horizonte” hospital, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

de Moraes Rodrigues, J., Souza de Lima, D., Leal, V.N. et al. Gain-of-function SNPs in NLRP3 and IL1B genes confer protection against obesity and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis?. Endocrine 60, 368–371 (2018). https://doi.org/10.1007/s12020-017-1343-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-017-1343-0

Search

Navigation